Professor Catharine West PhD

Photograph of Catharine West

Professor of Radiation Biology

Translational Radiobiology Group
Institute of Cancer Sciences
Radiotherapy Related Research
Christie Hospital NHS Trust
Wilmslow Road
Manchester
M20 4BX

Memberships of Committees and Professional Bodies

Association for Radiation Research
British Association for Cancer Research
British Institute of Radiology
European Society for Therapeutic Radiology and Oncology
Royal College of Radiology (Honorary)
Radiation Research Society (USA)
Fellow of the British Institute of Radiology (Honorary)
NCRI CTRad
LH Gray Cancer Memorial Trust
Committee on Medical Aspects of Radiation in the Environment (COMARE)
Prostate Cancer UK Research Advisory Committee
NCRI Sarcoma CSG (2010-2013)
NCRI Head & Neck CSG (2006-2013)
Cancer Research UK TRICC/BIDD (2004-2009)

Research

The challenge for radiotherapy-related research is to find ways of giving as much radiation as possible to kill cancer cells while minimising the doses received by surrounding healthy tissue. The expansion of our knowledge through the Human Genome Project has been accompanied by the development of new high-throughput techniques, which provide extensive capabilities for the analysis of a large number of genes or the whole genome. There is a belief that this genomic revolution, i.e. sequencing of the human genome and developments in high throughput technology, heralds a future of personalised medicine. For radiotherapy, this progress should increase the possibility of predicting individual patient response to radiotherapy. The Translational Radiobiology Group, therefore, is interested in the characterisation of molecular profiles that reflect relevant biological phenotypes and predict tumour and normal tissue response to radiation.

Teaching

  • Postgraduate Research Committee, Institute of Cancer Sciences
  • MRes Oncology Programme Committee
  • Unit Leader (Lecture Series), MRes Oncology
  • Supervisor for medical student projects
  • Supervision for MRes student projects
  • Supervison of PhD and MD students
  • Internal and external PhD/MD examiner
  • Christie School of Oncology FRCR Part I radiobiology course
  • MSc Radiobiology (Oxford University)
  • MSc Oncology (Nottingham University)

Social Responsibility

Involved in several national  committees including:

  • Chair, LH Gray Memorial Trust set up to futher the public the knowledge and understanding of all aspects and all applications of radiation sciences.
  • Member of COMARE (Committee on Medical Aspects of Radiation in the Environment) set up to advises the government on the health effects of natural and man-made radiation, both ionising and non-ionising.
  • Member of the CTRad (Clinical and Translational Radiotherapy Research Working Group) set up by the National Cancer Research Institute in 2009 to focus on clinical and translational issues relating to radiotherapy and radiobiology, as well as developing a portfolio of practice-changing trials. CTRad has also been tasked with actively promoting translation of new discoveries into practice.

Biography

Catharine West is a Professor of Radiation Biology at the University of Manchester. She studied biology at York University and radiobiology at the Institute of Cancer Research, Sutton.  After postdoctoral work at the University of Rochester Cancer Centre in upstate New York, she moved to Manchester in 1986. In 2002, she joined the Institute of Cancer Sciences at the University of Manchester and established the Translational Radiobiology Group.  Her research focuses on trying to predict how cancer patients respond to radiotherapy with a particular interest in measuring radiosensitivity and hypoxia.  She was instrumental in setting up an international Radiogenomics Consortium, which is identifying the genetic determinants of radiotherapy toxicity.  She is a chief investigator (RAPPER, REQUITE) or translational lead (NIMRAD, VORTEX, CIRCCa) for national/international studies.  Current committee work includes CTRad, COMARE, the LH Gray Memorial Trust, and the editorial boards of Radiation Research, Physics in Medicine & Biology and Clinical Oncology. She has published over 200 papers, an honorary member of the Royal College of Radiology and an honorary fellow of the British Institute of Radiology.

Publications

2016

  • Irlam, J., Eustace, A., Denley, H., Choudhury, A., Harris, A. L., Hoskin, P. J., & West, C. (2016). Expression of miR-210 in relation to other measures of hypoxia and prediction of benefit from hypoxia modification in patients with bladder cancer. British Journal of Cancer. . Publication link: d0aa965a-3917-43a1-9341-a479fb8b2423

2015

  • Bernstein, J. M., Andrews, T. D., Slevin, N. J., West, C. M. L., & Homer, J. J. (2015). Prognostic value of hypoxia-associated markers in advanced larynx and hypopharynx squamous cell carcinoma.The Laryngoscope, 125(1). DOI:10.1002/lary.24933. Publication link: 5f3ef13a-ff9a-4ff7-a244-a8772c0aebc1 | PubMed:25230150
  • Bernstein, J. M., Kershaw, L. E., Withey, S. B., Lowe, N. M., Homer, J. J., Slevin, N. J., ... West, C. M. (2015). Tumor plasma flow determined by dynamic contrast-enhanced MRI predicts response to induction chemotherapy in head and neck cancer. Oral Oncology, 51(5), 508-13. DOI:10.1016/j.oraloncology.2015.01.013. Publication link: 0feba876-3b27-41f2-9264-7d0342837fe3 | PubMed:25700703
  • Dickie, B. R., Banerji, A., Kershaw, L. E., McPartlin, A., Choudhury, A., West, C. M., & Rose, C. J. (2015). Improved accuracy and precision of tracer kinetic parameters by joint fitting to variable flip angle and dynamic contrast enhanced MRI data. Magnetic Resonance in Medicine. DOI:10.1002/mrm.26013. Publication link: 3afe932b-cec9-4369-a0d8-ead9af43756a | PubMed:26480291
  • West, C. M., Dorling, L., Barnett, G. C., Michailidou, K., Coles, C. E., Burnet, N. G., ... Pharoah, P. D. (2015). Patients with a high polygenic risk of breast cancer do not have an increased risk of radiotherapy toxicity. Clinical Cancer Research. . Publication link: 6e0f424d-5448-4ced-a078-2c6e156cd1aa
  • West, C. M., Oguejiofor, K., Hall, J., Slater, C., Betts, G., Hall, G., ... Stern, P. L. (2015). Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma. B J C, 113, 886-893. . Publication link: 4ec44942-bd3b-4d76-a48f-4c6393081397
  • West, C. M., Seibold, P., Behrens, S., Schmezer, P., Helmbold, I., Barnett, G., ... Chang-Claude, J. (2015). XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients.International Journal of Radiation: Oncology - Biology - Physics, 92, 1084-1092. . Publication link: 45567e1c-ac1f-469e-95f3-c89046c48797
  • West, C. M., Symonds, R. P., Gourley, C., Davidson, S., Carty, K., McCartney, E., ... Paul, J. (2015). Cediranib combined with carboplatin and paclitaxel in patients with metastatic or recurrent cervical cancer (CIRCCa): a randomised, double-blind, placebo-controlled phase 2 trial. The Lancet Oncology, 16, 1515-1524. . Publication link: 877138da-43cf-4901-a59b-e58ebd5676ab
  • West, C., Fleming, I. N., Manavaki, R., Blower, P. J., Williams, K. J., Harris, A. L., ... Gilbert, F. J. (2015). Imaging tumour hypoxia with positron emission tomography.B J C, 112, 238-250. . Publication link: ec937f3b-c58e-47eb-977c-fe299f51a185

2014

  • Barnett, G. C., Thompson, D., Fachal, L., Kerns, S., Talbot, C., Elliott, R. M., ... West, C. M. L. (2014). A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity. Radiotherapy and Oncology, 111(2), 178-185. DOI:10.1016/j.radonc.2014.02.012. Publication link: 45c4d95f-9bfd-4b78-b770-7e612c705772 | PubMed:24785509
  • Bernstein, J. M., Homer, J. J., & West, C. M. (2014). Dynamic contrast-enhanced magnetic resonance imaging biomarkers in head and neck cancer: Potential to guide treatment? A systematic review. Oral Oncology, 50(10), 963-970. DOI:10.1016/j.oraloncology.2014.07.011. Publication link: 661417ff-43dc-4eeb-885b-69f76abc7dfd | PubMed:25116700
  • Betts, G., Valentine, H., Pritchard, S., Swindell, R., Williams, V., Morgan, S., ... Womack, C. (2014). FGFR2, HER2 and cMet in gastric adenocarcinoma: Detection, prognostic significance and assessment of downstream pathway activation. Virchows Archiv, 464(2), 145-156. DOI:10.1007/s00428-013-1517-y. Publication link: aaea9ab8-d39e-467f-a158-8cde01b457db | PubMed:24306956
  • Fachal, L., Gómez-Caamaño, A., Barnett, G. C., Peleteiro, P., Carballo, A. M., Calvo-Crespo, P., ... Vega, A. (2014). A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1. Nature Genetics, 46(8), 891-894. DOI:10.1038/ng.3020. Publication link: fd2c5223-b369-4525-acd7-99e9ac3c4b3d
  • Gurung, P. M. S., Veerakumarasivam, A., Williamson, M., Counsell, N., Douglas, J., Tan, W. S., ... Kelly, J. D. (2014). Loss of expression of the tumour suppressor gene AIMP3 predicts survival following radiotherapy in muscle-invasive bladder cancer. International Journal of Cancer. DOI:10.1002/ijc.29022. Publication link: 8f17478f-2f5c-456a-8878-ddd5e06efed4 | PubMed:24917520
  • Hall, J. S., Iype, R., Senra, J., Taylor, J., Armenoult, L., Oguejiofor, K., ... West, C. M. L. (2014). Investigation of radiosensitivity gene signatures in cancer cell lines. PLoS ONE, 9(1), [e86329]. DOI:10.1371/journal.pone.0086329. Publication link: 080a751f-c251-4948-8e70-52bdbd2b0d78 | PubMed:24466029
  • Hunter, B. A., Eustace, A., Irlam, J. J., Valentine, H. R., Denley, H., Oguejiofor, K. K., ... West, C. M. (2014). Expression of hypoxia-inducible factor-1α predicts benefit from hypoxia modification in invasive bladder cancer. British Journal of Cancer, 111(3), 437-443. DOI:10.1038/bjc.2014.315. Publication link: 5d14e6bc-ae94-4405-86e8-e0a717498eb4 | PubMed:24937673
  • Kerns, S. L., Ruysscher, D. D., Andreassen, C. N., Azria, D., Barnett, G. C., Chang-Claude, J., ... Bentzen, S. M. (2014). STROGAR - STrengthening the Reporting of Genetic Association studies in Radiogenomics. Radiotherapy and Oncology, 110(1), 182-188. DOI:10.1016/j.radonc.2013.07.011. Publication link: fe752441-6742-4ba8-aa46-d008a6198dc9 | PubMed:23993398
  • Mirza, A., Foster, L., Valentine, H., Welch, I., West, C. M., & Pritchard, S. (2014). Investigation of the epithelial to mesenchymal transition markers S100A4, vimentin and Snail1 in gastroesophageal junction tumors. Diseases of the Esophagus, 27(5), 485-492. DOI:10.1111/j.1442-2050.2012.01435.x. Publication link: 7fc4b487-99d9-45bc-8c0a-0ad2b80756b9 | PubMed:23082947
  • Valle, J., Rembielak, A. I., Jain, P., Jackson, A. S., Green, M. M., Santorelli, G. R., ... Price, P. M. (2014). Phase II Trial of Cetuximab and Conformal Radiotherapy Only in Locally Advanced Pancreatic Cancer with Concurrent Tissue Sampling Feasibility Study. Translational Oncology, 7(1), 55-64. DOI:10.1593/tlo.13724. Publication link: 0e1b98f7-3afa-4262-841a-8c9c1a2c31c3 | PubMed:24772208
  • West, C. M., Kerns, S. L., Andreassen, C. N., Barnett, G. C., Bentzen, S. M., Burnet, N. G., ... Rosenstein, B. S. (2014). Radiogenomics: the search for genetic predictors of radiotherapy response. Future Oncology, 10, 2391-2406. . Publication link: 52dc2e64-2a06-49f8-a366-494797e2d87c
  • West, C. M., Kerns, S. L., Andreassen, C. N., Barnett, G. C., Bentzen, S. M., Burnet, N. G., ... Rosenstein, B. S. (2014). Radiogenomics: the search for genetic predictors of radiotherapy response. Future Oncology, 26, 739-742. . Publication link: 8eb01433-95eb-4a1f-b35a-ff806bbea496
  • West, C. M., Rosenstein, B. S., Bentzen, S. M., Alsner, J., Andreassen, C. N., Azria, D., ... Zenhausern, F. (2014). Radiogenomics: radiobiology enters the era of big data and team science. International Journal of Radiation: Oncology - Biology - Physics, 89, 1709-1713. . Publication link: 37ddf7a6-f7ff-41af-8f3e-cacbd9bc2470
  • West, C., Azria, D., Chang-Claude, J., Davidson, S., Lambin, P., Rosenstein, B., ... Yuille, M. (2014). The REQUITE Project: Validating Predictive Models and Biomarkers of Radiotherapy Toxicity to Reduce Side-effects and Improve Quality of Life in Cancer Survivors. Clinical Oncology, 26, 739-742. . Publication link: 9f219f26-3176-41fd-927d-ee82161159eb
  • West, C., Thomson, D., Yang, H., Baines, H., Miles, E., Bolton, S., & Slevin, N. (2014). NIMRAD - A Phase III Trial to Investigate the Use of Nimorazole Hypoxia Modification with Intensity-modulated Radiotherapy in Head and Neck Cancer. Unknown Journal, 26, 344-347. . Publication link: ece74456-b70e-4ed0-b3ee-42c092985fba
  • West, C., Thomson, D., Yang, H., Baines, H., Miles, E., Bolton, S., & Slevin, N. (2014). Use of Nimorazole Hypoxia Modification with Intensity-modulated Radiotherapy in Head and Neck Cancer. Clinical Oncology, 26, 344-347. . Publication link: 2dc8d2db-9bb5-4efc-97d9-16d13e9e8b51

2013

  • Bernstein, J. M., Bernstein, C. R., West, C. M. L., & Homer, J. J. (2013). Molecular and cellular processes underlying the hallmarks of head and neck cancer. European Archives of Oto-Rhino-Laryngology, 270(10), 2585-2593. DOI:10.1007/s00405-012-2323-x. Publication link: 641526a2-0443-4468-a1c6-f767e3f3b4b6 | PubMed:23263268
  • Bernstein, J., Douglas, C. M., Bernstein, J. M., Ormston, V. E., Hall, R. C., Merve, A., ... Homer, J. J. (2013). Lack of Prognostic Effect of Carbonic Anhydrase-9, Hypoxia Inducible Factor-1α and Bcl-2 in 286 Patients with Early Squamous Cell Carcinoma of the Glottic Larynx Treated with Radiotherapy. Clinical Oncology, 25(1), 59-65. DOI:10.1016/j.clon.2012.07.004. Publication link: 7ad2e6a0-682b-45ca-883f-d5653391a210 | PubMed:22841149
  • Betts, G. N. J., Eustace, A., Patiar, S., Valentine, H. R., Irlam, J., Ramachandran, A., ... West, C. M. L. (2013). Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma. European Journal of Cancer, 49(1), 156-165. DOI:10.1016/j.ejca.2012.07.028. Publication link: 49857c72-ebbb-4f13-b0b9-408769cafb11
  • Eustace, A., Irlam, J. J., Taylor, J., Denley, H., Agrawal, S., Choudhury, A., ... West, C. M. L. (2013). Necrosis predicts benefit from hypoxia-modifying therapy in patients with high risk bladder cancer enrolled in a phase III randomised trial. Radiotherapy and Oncology, 108(1), 40-47. DOI:10.1016/j.radonc.2013.05.017. Publication link: 61873367-4f81-4f7a-b4fc-d6f72632e265
  • Hall, J. S., Iype, R., Armenoult, L. S. C., Taylor, J., Miller, C. J., Davidson, S., ... West, C. M. L. (2013). Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity. International Journal of Radiation Oncology Biology Physics, 85(5), e223-e229. DOI:10.1016/j.ijrobp.2012.11.030. Publication link: 13c797c5-54b2-4894-8235-285af487d55a | PubMed:23332225
  • Henson, C. C., Anandadas, C. N., Barraclough, L. H., Swindell, R., West, C. M. L., & Davidson, S. E. (2013). The case for including bowel urgency in toxicity reporting after pelvic cancer treatment. JNCCN Journal of the National Comprehensive Cancer Network, 11(7), 827-833. . Publication link: 6869d0e4-70df-481a-9c21-afbfe586d0d6 | PubMed:23847219
  • Hughes, C., Iqbal-Wahid, J., Brown, M., Shanks, J. H., Eustace, A., Denley, H., ... Gardner, P. (2013). FTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder.Journal of biophotonics, 6(1), 73-87. DOI:10.1002/jbio.201200126. Publication link: 7e991d12-64be-4868-a911-95ca3966173b | PubMed:23125109
  • Mirza, A., Brown, M., McNulty, C., Valentine, J., Annesley, A., Galloway, S., ... Pritchard, S. (2013). A pilot study to investigate the role of thymidylate synthase as a marker of prognosis for neoadjuvant chemotherapy in gastric and gastro-oesophageal junction adenocarcinoma. Gastroenterology Research and Practice, 2013, [502153]. DOI:10.1155/2013/502153. Publication link: 618c7b32-28a4-41eb-b839-01638643d14b | PubMed:23533389
  • Oguejiofor, K. K., Hall, J. S., Mani, N., Douglas, C., Slevin, N. J., Homer, J., ... West, C. M. L. (2013). The prognostic significance of the biomarker p16 in oropharyngeal squamous cell carcinoma. Clinical Oncology, 25(11), 630-638. DOI:10.1016/j.clon.2013.07.003. Publication link: 4b5e5039-69bc-42ea-a6d7-25a1ca8f4f7f | PubMed:23916365
  • West, C. M., Burnet, N. G., Barnett, G. C., Elliott, R. M., Dearnaley, D. P., Pharoah, P. D., & Dunning, A. M. (2013). RAPPER: The Radiogenomics of Radiation Toxicity. Unknown Journal, 25, 431-433. . Publication link: 0bbe9b78-332e-4ac2-bc49-0c89efe7cc4a

2012

  • Andreassen, C. N., Dikomey, E., Parliament, M., & West, C. M. L. (2012). Will SNPs be useful predictors of normal tissue radiosensitivity in the future?. Radiotherapy and Oncology, 105(3), 283-288. DOI:10.1016/j.radonc.2012.11.003. Publication link: 8dcdc0ea-ee31-4c2d-889a-46e15c79db80 | PubMed:23245645
  • Barnett, G. C., Coles, C. E., Elliott, R. M., Baynes, C., Luccarini, C., Conroy, D., ... West, C. M. L. (2012). Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: A prospective analysis study. Lancet Oncology, 13(1), 65-77. DOI:10.1016/S1470-2045(11)70302-3. Publication link: eeced5ea-4427-4a45-8642-b5677627af3e
  • Barnett, G. C., Elliott, R. M., Alsner, J., Andreassen, C. N., Abdelhay, O., Burnet, N. G., ... Bentzen, S. M. (2012). Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity. Radiotherapy and Oncology, 105(3), 289-295. DOI:10.1016/j.radonc.2012.10.017. Publication link: 9069b13d-175f-4602-bc00-ad6192bda025 | PubMed:23199655
  • Betts, G. N., Eustace, A., Patiar, S., Valentine, H. R., Irlam, J., Ramachandran, A., ... West, C. M. (2012). Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma.Eur J Cancer. . Publication link: cbb75c29-d39c-468d-a591-ca8c4f25ac24
  • Dibb, M., Han, N., Choudhury, J., Hayes, S., Valentine, H., West, C., ... Sharrocks, A. D. (2012). The FOXM1-PLK1 axis is commonly upregulated in oesophageal adenocarcinoma. British Journal of Cancer, 107(10), 1766-1775. DOI:10.1038/bjc.2012.424. Publication link: 225261f4-8376-4ab5-93e3-2c692bffc297 | PubMed:23037713
  • Douglas, C. M., Bernstein, J. M., Ormston, V. E., Hall, R. C., Merve, A., Swindell, R., ... Homer, J. J. (2012). Lack of Prognostic Effect of Carbonic Anhydrase-9, Hypoxia Inducible Factor-1α and Bcl-2 in 286 Patients with Early Squamous Cell Carcinoma of the Glottic Larynx Treated with Radiotherapy. Clin Oncol, 24(Epub). . Publication link: db789822-63ab-46ca-8e68-2bcc8636e50b
  • Hall, J. S., Taylor, J., Valentine, H. R., Irlam, J. J., Eustace, A., Hoskin, P. J., ... West, C. M. L. (2012). Enhanced stability of microRNA expression facilitates classification of FFPE tumour samples exhibiting near total mRNA degradation. British Journal of Cancer, 107(4), 684-694. DOI:10.1038/bjc.2012.294. Publication link: b8fb45e1-5ad5-4ef9-b99f-1095ca633c71 | PubMed:22805332
  • Lo, L., Valentine, H., Harrison, J., Hayes, S., Welch, I., Pritchard, S., ... Ang, Y. (2012). Tissue factor expression in the metaplasia-adenoma-carcinoma sequence of gastric cancer in a European population. British Journal of Cancer, 107(7), 1125-1130. DOI:10.1038/bjc.2012.363. Publication link: d54b6cda-3970-40ab-a934-e6e0ce41a9f9 | PubMed:22929889
  • Lyons, A. J., West, C. M., Risk, J. M., Slevin, N. J., Chan, C., Crichton, S., ... Shaw, R. J. (2012). Osteoradionecrosis in head-and-neck cancer has a distinct genotype-dependent cause.International journal of radiation oncology, biology, physics, 82(4). DOI:10.1016/j.ijrobp.2011.05.016. Publication link: de9efcae-a59d-4e5f-a5c3-e4bedf058355 | PubMed:21708430
  • Talbot, C. J., Tanteles, G. A., Barnett, G. C., Burnet, N. G., Chang-Claude, J., Coles, C. E., ... Symonds, R. P. (2012). A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy. British Journal of Cancer, 107(4), 748-753. DOI:10.1038/bjc.2012.290. Publication link: 7d64e1e2-ccba-4915-a97d-780caa86483b
  • West, C., & Mirza, A. N. A. H. S. F. L. W. I. W. C. M. P. S. (2012). Assessment of Histopathological Response in Gastric and Gastro-Oesophageal Junction Adenocarcinoma following Neoadjuvant Chemotherapy: Which Scoring System to Use?. Pathology. DOI:10.5402/2012/519351. Publication link: 68c4dc58-08aa-4713-8c1c-2ef9bf97c200
  • Zhou, C., Simpson, K. L., Lancashire, L. J., Walker, M. J., Dawson, M. J., Unwin, R. D., ... Whetton, A. D. (2012). Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery.Journal of Proteome Research, 11(4), 2103-2113. DOI:10.1021/pr200636x. Publication link: 3dba3778-45e7-4a67-b8e3-2414718d8b0c | PubMed:22338609

2011

  • Barnett, G. C., West, C. M. L., Elliott, R. M., Dearnaley, D., Coles, C. E., Sydes, M., ... Bentzen, S. (2011). The STAT Score: A cumulative score of radiation toxicity for use in radiogenomics studies.Int J Radiat Oncol Biol Phys, 82, 1065-1074. . Publication link: f7f13541-be61-45a6-bbc9-9a20b18a6aac
  • Challen, C., Brown, H., Cai, C., Betts, G., Paterson, I., Sloan, P., ... Robinson, M. (2011). Mitochondrial DNA mutations in head and neck cancer are infrequent and lack prognostic utility.British Journal of Cancer, 104(8). DOI:10.1038/bjc.2011.96. Publication link: 056e8fe7-e40a-44fb-84f1-efa818af8be9 | PubMed:21427725
  • Donaldson, S. B., Betts, G., Bonington, S. C., Homer, J. J., Slevin, N. J., Kershaw, L. E., ... Buckley, D. L. (2011). Perfusion estimated with rapid dynamic contrast-enhanced magnetic resonance imaging correlates inversely with vascular endothelial growth factor expression and pimonidazole staining in head-and-neck cancer: A pilot study. International Journal of Radiation Oncology Biology Physics, 81(4), 1176-1183. DOI:10.1016/j.ijrobp.2010.09.039. Publication link: 3bb801d1-0b38-4c39-a91b-a0131c129189
  • Egelmeer, A. G. T. M., Velazquez, E. R., De Jong, J. M. A., Oberije, C., Geussens, Y., Nuyts, S., ... Lambin, P. (2011). Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: A cohort study based on 994 patients. Radiotherapy and Oncology, 100(1), 108-115. DOI:10.1016/j.radonc.2011.06.023. Publication link: 81fc85f0-3e26-44a4-9b62-4708193bd937
  • Gee, H. E., Buffa, F. M., Camps, C., Ramachandran, A., Leek, R., Taylor, M., ... Harris, A. L. (2011). The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis. British Journal of Cancer, 104(7), 1168-1177. DOI:10.1038/sj.bjc.6606076. Publication link: 48a7e6ec-db9b-4965-99ac-90f2b4abd20c
  • Hall, J. S., Leong, H. S., Armenoult, L. S. C., Newton, G. E., Valentine, H. R., Irlam, J. J., ... West, C. M. L. (2011). Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples. British Journal of Cancer, 104(6), 971-981. DOI:10.1038/bjc.2011.66. Publication link: f1c117a6-3bc8-4616-8dd0-f8090447c6a7 | PubMed:21407225
  • West, C. M., & Barnett, G. C. (2011). Genetics and genomics of radiotherapy toxicity: Towards prediction. Genome Medicine, 3(8), [52]. DOI:10.1186/gm268. Publication link: d25e69bb-8a8e-4cf5-a8f9-c3776b16e481
  • West, C., Marcu, L. G. (Ed.), & Bezak, E. (Ed.) (2011). Molecular targeting for improving the outcome of radiotherapy. In Recent Advances Research Updates: Medical Physics and Radiobiology. (pp. 81-90). Kerala, India: Researchman Publishers PVT Ltd. . Publication link: 9804b726-11c8-43ae-b3fb-31a2afafe582

2010

  • Barnett, G. C., Coles, C. E., Burnet, N. G., Pharoah, P. D., Wilkinson, J., West, C. M., ... Dunning, A. M. (2010). No association between SNPs regulating TGF-beta1 secretion and late radiotherapy toxicity to the breast: Results from the RAPPER study.Radioth Oncol, 97, 9-14. . Publication link: 622f1cbc-0c21-4b7e-9dda-e91c65429789
  • Brown, M., Sillah, K., Griffiths, E. A., Swindell, R., West, C. M., Page, R. D., ... Pritchard, S. A. (2010). Tumour budding and a low host inflammatory response are associated with a poor prognosis in oesophageal and gastro-oesophageal junction cancers.Histopathology, 56(7). DOI:10.1111/j.1365-2559.2010.03559.x. Publication link: 5d374fbe-f478-4c15-912c-22be9d7afe56 | PubMed:20636792
  • Buffa, F. M., Harris, A. L., West, C. M., & Miller, C. J. (2010). Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene. British Journal of Cancer, 102(2), 428-435. DOI:10.1038/sj.bjc.6605450. Publication link: 41352f15-a9d7-4cc9-8a33-538947b36f78 | PubMed:20087356
  • Burrows, N., Resch, J., Cowen, R. L., Von Wasielewski, R., Hoang-Vu, C., West, C. M., ... Brabant, G. (2010). Expression of hypoxia-inducible factor 1α in thyroid carcinomas. Endocrine-Related Cancer, 17(1), 61-72. DOI:10.1677/ERC-08-0251. Publication link: cbd270c5-2b83-4308-b51c-ac064c45584a | PubMed:19808899
  • Donaldson, S. B., Buckley, D. L., O'Connor, J. P., Davidson, S. E., Carrington, B. M., Jones, A. P., & West, C. M. L. (2010). Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix. British Journal of Cancer, 102(1), 23-26. DOI:10.1038/sj.bjc.6605415. Publication link: fef6d507-a767-470b-a67d-2f89d6bdebb9
  • Donaldson, S. B., West, C. M. L., Davidson, S. E., Carrington, B. M., Hutchison, G., Jones, A. P., ... Buckley, D. L. (2010). A comparison of tracer kinetic models for T1-weighted dynamic contrast-enhanced MRI: application in carcinoma of the cervix.Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 63(3). DOI:10.1002/mrm.22217. Publication link: 7ddf903c-69bd-4d0e-ac4a-df91a2c97c09 | PubMed:20187179
  • Farnell, D. J. J., Mandall, P., Anandadas, C., Routledge, J., Burns, M. P., Logue, J. P., ... Davidson, S. E. (2010). Development of a patient-reported questionnaire for collecting toxicity data following prostate brachytherapy. Radiotherapy and Oncology, 97(1), 136-142. DOI:10.1016/j.radonc.2010.05.011. Publication link: 0ad50bf7-4129-40ab-a514-e80961db9a83 | PubMed:20561698
  • Gee, H. E., Camps, C., Buffa, F. M., Patiar, S., Winter, S. C., Betts, G., ... Harris, A. L. (2010). hsa-mir-210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer.Cancer, 116(9). DOI:10.1002/cncr.25009. Publication link: c737bbf1-91d4-4cf1-b0bf-6b811696bddc | PubMed:20187102
  • Hannigan, A., Smith, P., Kalna, G., Lo Nigro, C., Orange, C., O'Brien, D. I., ... Inman, G. J. (2010). Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.The Journal of clinical investigation, 120(8). DOI:10.1172/JCI36125. Publication link: e8eab8c2-c676-41a2-95c1-15ecffcec9f9 | PubMed:20592473
  • Mehanna, H., Paleri, V., West, C. M. L., & Nutting, C. (2010). Head and neck cancer--Part 1: Epidemiology, presentation, and prevention.BMJ (Clinical research ed.), 341. . Publication link: a3ec1b59-b053-4e12-962e-9e3963399f2c | PubMed:20855405
  • Mehanna, H., West, C. M. L., Nutting, C., & Paleri, V. (2010). Head and neck cancer--Part 2: Treatment and prognostic factors.BMJ (Clinical research ed.), 341. . Publication link: 069d03bf-f293-4284-9989-6153c786cd50 | PubMed:20876637
  • Robson, T., & West, C. (2010). Radiation and the genome: From risks to opportunities for therapeutic exploitation. British Journal of Radiology, 83(992), 635-637. DOI:10.1259/bjr/31552255. Publication link: f10b6f59-3cf6-420d-bbd9-9fdac62e23e7
  • Sillah, K., Williams, L. R., Laasch, H-U., Saleem, A., Watkins, G., Pritchard, S. A., ... Welch, I. M. (2010). Computed tomography overestimation of esophageal tumor length: Implications for radiotherapy planning.World journal of gastrointestinal oncology, 2(4). DOI:10.4251/wjgo.v2.i4.197. Publication link: cae384f4-3e91-4863-9318-dae30d9f605b | PubMed:21160598
  • Silva, P., Slevin, N. J., Sloan, P., Valentine, H., Ryder, D., Price, P., ... Homer, J. J. (2010). Use of multiple biological markers in radiotherapy-treated head and neck cancer.The Journal of laryngology and otology, 124(6). DOI:10.1017/S0022215110000228. Publication link: 42998753-cad6-4f48-bbd5-a4a0ea05f880 | PubMed:20388242
  • Thurlow, J. K., Murillo, C. L. P., Hunter, K. D., Buffa, F. M., Patiar, S., Betts, G., ... Kalna, G. (2010). Spectral clustering of microarray data elucidates the roles of microenvironment remodeling and immune responses in survival of head and neck squamous cell carcinoma. Journal of Clinical Oncology, 28(17), 2881-2888. DOI:10.1200/JCO.2009.24.8724. Publication link: af08e7a3-b76d-479c-bad2-cc3eb19f51b7
  • West, C., Rosenstein, B., Alsner, J., Azria, D., Barnett, G., Begg, A., ... Yarnold, J. (2010). Establishment of a Radiogenomics Consortium. Int J Radiat Oncol Biol Phys, 76, 1296-1296. . Publication link: 8dd48d42-3d48-48a9-808d-897fe1668305

2009

  • Barnett, G. C., West, C. M. L., Dunning, A. M., Elliott, R. M., Coles, C. E., Pharoah, P. D. P., & Burnet, N. G. (2009). Normal tissue reactions to radiotherapy: Towards tailoring treatment dose by genotype. Nature Reviews Cancer, 9(2), 134-142. DOI:10.1038/nrc2587. Publication link: 1fbe258f-0bb7-488c-a432-383703eda1fe
  • Davidson, S. E., Hendry, J. H., & West, C. M. (2009). Point: Why choose pulsed-dose-rate brachytherapy for treating gynecologic cancers?. Brachytherapy, 8(3), 269-272. DOI:10.1016/j.brachy.2009.06.004. Publication link: 4d7b6df0-3f12-4a71-98f2-7196bf60dfb4
  • Hedman, M., Bjrk-Eriksson, T., Mercke, C., West, C., Hesselius, P., & Brodin, O. (2009). Comparison of predicted and clinical response to radiotherapy: A radiobiology modelling study. Acta Oncologica, 48(4), 584-590. DOI:10.1080/02841860802637757. Publication link: ee61f425-5005-4d9e-ab19-a1eaab74595f
  • Kötz, B., West, C., Saleem, A., Jones, T., & Price, P. (2009). Blood flow and vd (water): Both biomarkers required for interpreting the effects of vascular targeting agents on tumor and normal tissue. Molecular Cancer Therapeutics, 8(2), 303-309. DOI:10.1158/1535-7163.MCT-08-1016. Publication link: 6e2e78c0-9778-4edb-be3a-9a94db4f1cc5
  • O'Connor, J. P. B., Naish, J. H., Parker, G. J. M., Waterton, J. C., Watson, Y., Jayson, G. C., ... Jackson, A. (2009). Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors. International Journal of Radiation Oncology Biology Physics, 75(4), 1209-1215. DOI:10.1016/j.ijrobp.2008.12.040. Publication link: 2af19f23-a06f-467e-9075-aa9dc60f111d | PubMed:19327904
  • Sillah, E., Griffiths, E. A., Pritcharrd, S. A., Swindell, R., West, C. M., Page, R., & Welch, I. M. (2009). Clinical impact of tomour involvement of the anastomotic doughnut in oesophagogastric cancer surgery. Annals of the Royal College of Surgeons of England, 91(3), 195-200. DOI:10.1308/003588409X359268. Publication link: 9548e55e-8a90-4389-b096-67b08a9640ba
  • Sillah, K., Pritchard, S. A., Watkins, G. R., McShane, J., West, C. M., Page, R., & Welch, I. M. (2009). The degree of circumferential tumour involvement as a prognostic factor in oesophageal cancer. European Journal of Cardio-thoracic Surgery, 36(2), 368-373. DOI:10.1016/j.ejcts.2008.12.052. Publication link: e9de880f-0455-4fb0-8aca-a8894bd5b887
  • West, C., West, C. M. L., & Davidson, S. E. (2009). Measurement tools for gastrointestinal symptoms in radiation oncology. Current Opinion in Supportive and Palliative Care, 3(1), 36-40. DOI:10.1097/SPC.0b013e328325d18d. Publication link: b31de99d-bf5e-4323-838e-93d3234dd193
  • West, C., West, C. M. L., Martin, C. J., Sutton, D. G., & Wright, E. G. (2009). 21st L H Gray Conference: The radiobiology/radiation protection interface. British Journal of Radiology, 82(977), 353-362. DOI:10.1259/bjr/8891994. Publication link: e5e2a4eb-7d45-4dba-9da7-3f494dda7c86

2008

  • Charnley, N., Airley, R., Du Plessis, D., West, C., Brock, C., Barnett, C., ... Price, P. (2008). No relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma. Oncology Reports, 20(3), 537-542. DOI:10.3892/or_00000039. Publication link: 84e73e34-7c30-4a50-8c61-f35353ddd3a3
  • Homer, J., Silva, P., Slevin, N. J., Sloan, P., Valentine, H., Cresswell, J., ... West, C. M. L. (2008). Prognostic Significance of Tumor Hypoxia Inducible Factor-1α Expression for Outcome After Radiotherapy in Oropharyngeal Cancer. International Journal of Radiation Oncology Biology Physics, 72(5), 1551-1559. DOI:10.1016/j.ijrobp.2008.07.051. Publication link: 3afb30d3-debf-4bea-8d10-3fe7e1ac7410
  • West, C., Griffiths, E. A., Pritchard, S. A., McGrath, S. M., Valentine, H. R., Price, P. M., ... West, C. M. L. (2008). Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosis. British Journal of Cancer, 98(5), 965-973. DOI:10.1038/sj.bjc.6604210. Publication link: 5dda7480-f675-4040-8cff-0f0202ba0b9f
  • West, C., West, C. M., Joseph, L., & Bhana, S. (2008). Epidermal growth factor receptor-targeted therapy. British Journal of Radiology, 81, S36-S44. DOI:10.1259/bjr/32798755. Publication link: 60098bff-569a-43bb-b53b-fe373f308cb8

2007

  • Green, M., Green, M. M. L., Hiley, C. T., Shanks, J. H., Bottomley, I. C., West, C. M. L., ... Stratford, I. J. (2007). Expression of vascular endothelial growth factor (VEGF) in locally invasive prostate cancer is prognostic for radiotherapy outcome. International Journal of Radiation Oncology Biology Physics, 67(1), 84-90. DOI:10.1016/j.ijrobp.2006.08.077. Publication link: d226fd06-270d-4aed-9832-27379b0cd5c8
  • Möller-Levet, C. S., West, C. M., & Miller, C. J. (2007). Exploiting sample variability to enhance multivariate analysis of microarray data. Bioinformatics, 23(20), 2733-2740. DOI:10.1093/bioinformatics/btm441. Publication link: 4bafac3f-7e5f-479e-af75-24322cc8b89f | PubMed:17827205
  • Silva, P., Homer, J. J., Slevin, N. J., Musgrove, B. T., Sloan, P., Price, P., & West, C. M. L. (2007). Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: A review. Clinical Otolaryngology, 32(5), 337-345. DOI:10.1111/j.1749-4486.2007.01544.x. Publication link: 294f87e1-2288-4572-959b-787935be2ee1
  • Silva, P., West, C. M., Slevin, N., Valentine, H., Ryder, W. D. J., Hampson, L., ... Thakkar, N. (2007). Tumor Epression of Major Vault Protein is an Adverse Prognostic Factor for Radiotherapy Outcome in Oropharyngeal Carcinoma. International Journal of Radiation Oncology Biology Physics, 69(1), 133-140. DOI:10.1016/j.ijrobp.2007.02.025. Publication link: 4234ef9d-21fa-4f66-8e1e-af0bc3e2b758 | PubMed:17459603
  • Valentine, H. R., West, C. M. L., Griffiths, E., Pritchard, S., McGrath, S., Price, P. M., & Welch, I. (2007). Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence.Br J Cancer, 96( 9). . Publication link: 20048928-2336-4d62-9cee-daf95f394593
  • Valentine, H. R., West, C. M. L., Griffiths, E., Pritchard, S., Whitchelo, N., Bishop, P., ... Welch, I. (2007). Hypoxia-inducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas.Br J Cancer, 96( 1). . Publication link: 76156c73-1158-4d28-b570-929533c7bc5d
  • West, C. M. L., Elliott, R. M., & Burnet, N. G. (2007). The Genomics Revolution and Radiotherapy. Clinical Oncology, 19(6), 470-480. DOI:10.1016/j.clon.2007.02.016. Publication link: f654144d-609f-4ade-971b-8e8f8ed83ed5
  • West, C. M. L. (2007). Radiotherapy predictive assays. In In Radiobiological Modelling in Radiation Oncology Eds R Dale & B Jones.. Publication link: 9f775156-fa3d-4e0e-ba2a-c68d45f667db

2006

  • Burnet, N. G., Elliott, R. M., Dunning, A., & West, C. M. L. (2006). Radiosensitivity, Radiogenomics and RAPPER. Clinical Oncology, 18(7), 525-528. DOI:10.1016/j.clon.2006.05.007. Publication link: db3f41a6-646e-48dc-a026-b02382462eec
  • Charnley, N., West, C. M., Barnett, C. M., Brock, C., Bydder, G. M., Glaser, M., ... Price, P. (2006). Early change in glucose metabolic rate measured using FDG-PET in patients with high-grade glioma predicts response to temozolomide but not temozolomide plus radiotherapy. International Journal of Radiation Oncology Biology Physics, 66(2), 331-338. DOI:10.1016/j.ijrobp.2006.04.043. Publication link: e8fcc9da-0ae3-4e47-8200-f394d9395a04
  • Isa, A. Y., Ward, T. H., West, C. M. L., Slevin, N. J., & Homer, J. J. (2006). Hypoxia in head and neck cancer. British Journal of Radiology, 79(946), 791-798. DOI:10.1259/bjr/17904358. Publication link: 83656f64-7f9d-443a-a2ea-91d53379e252
  • Kabuubi, P., Loncaster, J. A., Davidson, S. E., Hunter, R. D., Kobylecki, C., Stratford, I. J., & West, C. M. L. (2006). No relationship between thymidine phosphorylase (TP, PD-ECGF) expression and hypoxia in carcinoma of the cervix. British Journal of Cancer, 94(1), 115-120. DOI:10.1038/sj.bjc.6602882. Publication link: 7368bb2b-d641-4040-9170-92a4093e1974
  • Laking, G. R., West, C., Buckley, D. L., Matthews, J., & Price, P. M. (2006). Imaging vascular physiology to monitor cancer treatment. Critical Reviews in Oncology/Hematology, 58(2), 95-113. DOI:10.1016/j.critrevonc.2005.10.006. Publication link: 4d8d8a98-c62f-446a-9a01-ed12ce8d3a8d
  • Nordsmark, M., Loncaster, J., Aquino-Parsons, C., Chou, S. C., Gebski, V., West, C., ... Overgaard, J. (2006). The prognostic value of pimonidazole and tumour pO 2 in human cervix carcinomas after radiation therapy: A prospective international multi-center study. Radiotherapy and Oncology, 80(2), 123-131. DOI:10.1016/j.radonc.2006.07.010. Publication link: fc4defdd-4753-41bc-9a6c-b382ca49bb0d
  • West, C., & McKeown, S. (2006). Translational research in radiotherapy trials. British Journal of Radiology, 79(945), 716-718. DOI:10.1259/bjr/62971945. Publication link: 11ad6550-dac9-42b8-a5c2-59d1bce5c15e

2005

  • Airley, R. E., Phillips, R. M., Evans, A. E., Double, J., Burger, A. M., Feibig, H. H., ... Stratford, I. J. (2005). Hypoxia-regulated glucose transporter Glut-1 may influence chemosensitivity to some alkylating agents: results of EORTC (First Translational Award) study of the relevance of tumour hypoxia to the outcome of chemotherapy in human tumour-derived xenografts.International Journal of Oncology, 26(6), 1477-1484. . Publication link: 31076e4e-5ab0-4cca-8940-8e3232c94653
  • Faivre-Finn, C., Lee, L. W., Lorigan, P., West, C., & Thatcher, N. (2005). Thoracic radiotherapy for limited-stage small-cell lung cancer: Controversies and future developments. Clinical Oncology, 17(8), 591-598. DOI:10.1016/j.clon.2005.05.010. Publication link: 0b06b364-d9fc-4d2b-a85a-3e8997e06e47
  • Faivre-Finn, C., Lorigan, P., West, C., & Thatcher, N. (2005). Thoracic radiation therapy for limited-stage small-cell lung cancer: Unanswered questions. Clinical Lung Cancer, 7(1), 23-29. . Publication link: cfe1f736-cd5d-4720-9c51-e68f20c3ff8e
  • Green, M. M. L., Hutchison, G. J., Valentine, H. R., Fitzmaurice, R. J., Davidson, S. E., Hunter, R. D., ... Stratford, I. J. (2005). Expression of the proapoptotic protein Bid is an adverse prognostic factor for radiotherapy outcome in carcinoma of the cervix. British Journal of Cancer, 92(3), 449-458. DOI:10.1038/sj.bjc.6602344. Publication link: f8beaf70-38e6-4840-bb2c-f893e99233d7
  • West, C. M. L., & Charnley, N. (2005). The potential of PET to increase understanding of the biological basis of tumour and normal tissue response to radiotherapy. British Journal of Radiology, 78(28), 50-54. DOI:10.1259/bjr/83746792. Publication link: c414addd-17cc-41d4-9aa3-567cddedfec2
  • West, C. M. L., McKay, M. J., Hölscher, T., Baumann, M., Stratford, I. J., Bristow, R. G., ... Hendry, J. H. (2005). Molecular markers predicting radiotherapy response: Report and recommendations from an International Atomic Energy Agency technical meeting. International Journal of Radiation Oncology Biology Physics, 62(5), 1264-1273. DOI:10.1016/j.ijrobp.2005.05.001. Publication link: eae10b40-87f9-442b-a6ca-a40ed48e1e07

2004

  • Kim, J. Y., West, C. M. L., Valentine, H., Ward, T. H., Patterson, A. V., Stratford, I. J., ... Hendry, J. H. (2004). Cytotoxicity of the bioreductive agent RH1 and its lack of interaction with radiation. Radiotherapy and Oncology, 70(3), 311-317. DOI:10.1016/j.radonc.2003.12.008. Publication link: b251b5c3-d439-4354-8c79-683f1697eef7
  • West, C. M. L., & Price, P. M. (2004). Combretastatin A4 phosphate.Anticancer Drugs, 15( 3), 179-87. . Publication link: d873607a-f5dc-4eb9-a489-7d40c9c3a0f8
  • West, C. M. L., Jones, T., & Price, P. (2004). The potential of positron-emission tomography to study anticancer-drug resistance. Nature Reviews Cancer, 4(6), 457-469. . Publication link: f7d7b739-1b30-4ac8-bbca-299c9c04ec7a
  • West, C. M. L., Jones, T., & Price, P. M. (2004). Positron Emission Tomography (PET) and anticancer drug development. Discovery Medicine, 303-306. . Publication link: 3d8e4b9e-ab22-41a2-99b7-178f8bed256e
  • West, C. M. L., Price, P. M., Wells, P., Jones, T., & Harris, A. (2004). Measuring tumor pharmacodynamic response using PET proliferation probes: the case for 2-[(11)C]-thymidine.Biochim Biophys Acta, 1705( 2). . Publication link: 593b6aef-6ad0-45fc-b6be-18a8f70fdd55
  • West, C., Hutchison, G. J., Valentine, H. R., Loncaster, J. A., Davidson, S. E., Hunter, R. D., ... West, C. M. L. (2004). Hypoxia-inducible factor 1α expression as an intrinsic marker of hypoxia: Correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix. Clinical Cancer Research, 10(24), 8405-8412. DOI:10.1158/1078-0432.CCR-03-0135. Publication link: 34c7c208-b467-4a9e-95b6-0ccad8d9a2b6

2003

  • Cooper, R., Sarioǧlu, S., Sökmen, S., Füzün, M., Küpelioǧlu, A., Valentine, H., ... West, C. (2003). Glucose transporter-1 (GLUT-1): A potential marker of prognosis in rectal carcinoma?. British Journal of Cancer, 89(5), 870-876. DOI:10.1038/sj.bjc.6601202. Publication link: af2250c4-cc28-4ea4-b246-b3a59999e17d
  • Davidson, S. E., Burns, M. P., Routledge, J. A., Swindell, R., Bentzen, S. M., & West, C. M. L. (2003). Assessment of morbidity in carcinoma of the cervix: A comparison of the LENT SOMA scales and the Franco-Italian glossary. Radiotherapy and Oncology, 69(2), 195-200. DOI:10.1016/j.radonc.2003.09.005. Publication link: f7c720be-c638-4001-b40e-3367634033e7
  • Davidson, S., Routledge, J. A., Burns, M. P., Swindell, R., Khoo, V. S., West, C. M. L., & Davidson, S. E. (2003). Evaluation of the LENT-SOMA scales for the prospective assessment of treatment morbidity in cervical carcinoma. International Journal of Radiation Oncology Biology Physics, 56(2), 502-510. DOI:10.1016/S0360-3016(02)04578-9. Publication link: 9dbf623b-950d-4810-9564-97cb79226ce9
  • Nordsmark, M., Loncaster, J., Aquino-Parsons, C., Chou, S. C., Ladekarl, M., Havsteen, H., ... Raleigh, J. A. (2003). Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas. Radiotherapy and Oncology, 67(1), 35-44. DOI:10.1016/S0167-8140(03)00010-0. Publication link: 8bbacb43-c3a2-4d22-9b91-fa59dceaa799
  • Quarmby, S., Fakhoury, H., Levine, E., Barber, J., Wylie, J., Hajeer, A. H., ... Kumar, S. (2003). Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients. International Journal of Radiation Biology, 79(2), 137-143. . Publication link: 4bdf70a2-8650-4eb5-9273-c34e71f05550
  • West, C., Airley, R. E., Loncaster, J., Raleigh, J. A., Harris, A. L., Davidson, S. E., ... Stratford, I. J. (2003). Glut-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding. International Journal of Cancer, 104(1), 85-91. DOI:10.1002/ijc.10904. Publication link: 518b9fe9-015c-43ae-b08b-1716f592d1cb

2002

  • Appel, W., West, C. M. L., & Davidson, S. E. (2002). Late radiation morbidity in a patient with carcinoma of the cervix. Clinical Oncology, 14(6), 437-441. DOI:10.1053/clon.2002.0120. Publication link: 83b24182-663d-4e65-a40a-383ae12cda43
  • Baria, K., Warren, C., Eden, O. B., Roberts, S. A., West, C. M., & Scott, D. (2002). Chromosomal radiosensitivity in young cancer patients: Possible evidence of genetic predisposition. International Journal of Radiation Biology, 78(5), 341-346. DOI:10.1080/09553000110117359. Publication link: d45bb263-abae-4308-9b44-ebfadc7fd1e5
  • Davidson, S. E., Burns, M., Routledge, J., West, C. M. L., Swindell, R., Logue, J. P., ... Harris, M. A. (2002). Short report: A morbidity scoring system for clinical oncology practice: Questionaires produced from the LENT SOMA scoring system. Clinical Oncology, 14(1), 68-69. DOI:10.1053/clon.2001.0029. Publication link: 3701f5dc-c7db-420a-92c7-3dff14851e97
  • Dickson, J., Magee, B., Stewart, A., & West, C. M. L. (2002). Relationship between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiation reactions: A comparison of training and validation cohorts of breast cancer patients. Radiotherapy and Oncology, 62(3), 321-326. DOI:10.1016/S0167-8140(01)00432-7. Publication link: b7b260ee-714d-422e-8ebf-0b0b38656f9b
  • Quarmby, S., West, C., Magee, B., Stewart, A., Hunter, R., & Kumar, S. (2002). Differential expression of cytokine genes in fibroblasts derived from skin biopsies of patients who developed minimal or severe normal tissue damage after radiotherapy. Radiation Research, 157(3), 243-248. DOI:10.1667/0033-7587(2002)157[0243:DEOCGI]2.0.CO;2. Publication link: ea91d19c-ef37-4477-ad9b-03b64098f39b

2001

  • Airley, R., Loncaster, J., Davidson, S., Bromley, M., Roberts, S., Patterson, A., ... West, C. (2001). Glucose transporter Glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix. Clinical Cancer Research, 7(4), 928-934. . Publication link: e9057f90-bad4-4bb2-af77-a432f7a338ac
  • Baria, K., Warren, C., Roberts, S. A., West, C. M. L., Evans, D. G. R., Varley, J. M., & Scott, D. (2001). Correspondence re: A. Rothfuss et al., Induced micronucleus frequencies in peripheral blood lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer res., 60: 390-394, 2000 [1]. Cancer Research, 61(15), 5948-5949. . Publication link: 61794cd8-9413-40af-8efc-44cbd045e857
  • Baria, K., Warren, C., Roberts, S. A., West, C. M., & Scott, D. (2001). Chromosomal radiosensitivity as a marker of predisposition to common cancers?. British Journal of Cancer, 84(7), 892-896. DOI:10.1054/bjoc.2000.1701. Publication link: 38c92561-8021-4a91-b8ad-eb4a2ca7497a
  • Buffa, F. M., Davidson, S. E., Hunter, R. D., Nahum, A. E., & West, C. M. L. (2001). Incorporating biologic measurements (SF2, CFE) into a tumor control probability model increases their prognostic significance: A study in cervical carcinoma treated with radiation therapy. International Journal of Radiation Oncology Biology Physics, 50(5), 1113-1122. DOI:10.1016/S0360-3016(01)01584-X. Publication link: 924d39f7-0a56-4967-aa62-ae2822592dd6
  • Buffa, F. M., West, C., Byrne, K., Moore, J. V., & Nahum, A. E. (2001). Radiation response and cure rate of human colon adenocarcinoma spheroids of different size: The significance of hypoxia on tumor control modelling. International Journal of Radiation Oncology Biology Physics, 49(4), 1109-1118. DOI:10.1016/S0360-3016(00)01533-9. Publication link: f02c9c44-fff5-4484-83f3-a127645d6e61
  • Eastham, A. M., Atkinson, J., & West, C. M. L. (2001). Relationships between clonogenic cell survival, DNA damage and chromosomal radiosensitivity in nine human cervix carcinoma cell lines. International Journal of Radiation Biology, 77(3), 295-302. DOI:10.1080/09553000010017108. Publication link: 5eecf076-6e90-4c10-98fe-b2ccbaf80afa
  • Loncaster, J. A., Harris, A. L., Davidson, S. E., Logue, J. P., Hunter, R. D., Wycoff, C. C., ... West, C. M. L. (2001). Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Research, 61(17), 6394-6399. . Publication link: 976f06ea-e9b3-4dff-859a-ee0bcc6f1fc5
  • Nordsmark, M., Loncaster, J., Chou, S. C., Havsteen, H., Lindegaard, J. C., Davidson, S. E., ... Raleigh, J. A. (2001). Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma. International Journal of Radiation Oncology Biology Physics, 49(2), 581-586. DOI:10.1016/S0360-3016(00)01493-0. Publication link: 9b644680-d6e4-4df4-a62b-89f81236b4f3
  • Sheridan, M. T., & West, C. M. L. (2001). Ability to undergo apoptosis does not correlate with the intrinsic radiosensitivity (SF2) of human cervix tumor cell lines. International Journal of Radiation Oncology Biology Physics, 50(2), 503-509. DOI:10.1016/S0360-3016(01)01496-1. Publication link: 60e7bd3d-f9ed-4e4d-8514-5bb7afc66f29
  • West, C. M. L., Cooper, R. A., Loncaster, J. A., Wilks, D. P., & Bromley, M. (2001). Tumor vascularity: A histological measure of angiogenesis and hypoxia. Cancer Research, 61(7), 2907-2910. . Publication link: 49cd22c3-e62b-45d4-bea3-1468960e1f57
  • Buckley, D. L., West, C. M. L., Jones, A. A. P., Sykes, J. R., Carrington, B., Loncaster, J. A., & Todd, S. M. (2001). Prediction of clinical outcome for cancer of the cervix using dynamic contrast enhanced MR imaging. In International Society for Magnetic Resonance in Medicine 9th Annual Meeting. Glasgow. . Publication link: 325718bb-3e21-4182-a12b-f1796d822bd6

2000

  • Barber, J. B. P., West, C. M. L., Kiltie, A. E., Roberts, S. A., & Scott, D. (2000). Detection of individual differences in radiation-induced apoptosis of peripheral blood lymphocytes in normal individuals, ataxia telangiectasia homozygotes and heterozygotes, and breast cancer patients after radiotherapy. Radiation Research, 153(5 I), 570-578. . Publication link: d7ed34ac-2d62-417a-9caa-e4f42ad371b9
  • Björk-Eriksson, T., West, C., Karlsson, E., & Mercke, C. (2000). Tumor radiosensitivity (SF2) is a prognostic factor for local control in head and neck cancers. International Journal of Radiation Oncology Biology Physics, 46(1), 13-19. DOI:10.1016/S0360-3016(99)00373-9. Publication link: 66389c28-60c3-46dc-a613-6c5436b35596
  • Cooper, R. A., Carrington, B. M., Loncaster, J. A., Todd, S. M., Davidson, S. E., Logue, J. P., ... West, C. M. L. (2000). Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix. Radiotherapy and Oncology, 57(1), 53-59. DOI:10.1016/S0167-8140(00)00259-0. Publication link: a04cc831-2ad1-45eb-bfe6-b5787c18deb1
  • Davidson, S. E., West, C. M. L., Dickson, J., & Hunter, R. D. (2000). Pretreatment plasma TGFb1 levels are prognostic for survival but not morbidity following radiation therapy of carcinoma of the cervix. International Journal of Radiation Oncology Biology Physics, 48, 991-995. . Publication link: 5da3ef12-17e8-4410-a7be-96c73686beaf
  • Davidson, S. E., West, C. M. L., Loncaster, J. A., Cooper, R. A., Logue, J. P., & Hunter, R. D. (2000). Vascular endothelial growth factor (VEGF) expression is a prognostic factor for radiotherapy outcome in advanced carcinoma of the cervix.British Journal of Cancer, 83, 620-625. . Publication link: 10a94301-0ca1-4a0c-bfbb-74545932f080
  • West, C. M. L., Sheridan, M. T., Cooper, R. A., Stratford, I. J., Logue, J. P., Davidson, S. E., & Hunter, R. D. (2000). Pre-treatment apoptosis in carcinoma of the cervix correlates with changes in tumour oxygenation during.Br. J. Cancer, 82, 1177-1182. . Publication link: 25b88b55-7d44-44a2-9f0c-58c8f332b517
  • Wilson, C. R., Davidson, S. E., Margison, G. P., Jackson, S. P., Hendry, J. H., & West, C. M. L. (2000). Expression of Ku70 correlates with survival in carcinoma of the cervix. British Journal of Cancer, 83(12), 1702-1706. DOI:10.1054/bjoc.2000.1510. Publication link: 912bc31c-c8fb-4f08-b8dc-1729b5f6743a

1999

  • Björk-Eriksson, T., West, C. M. L., Cvetskovska, E., Svensson, M., Karlsson, E., Magnusson, B., ... Mercke, C. (1999). The lack of correlation between proliferation (Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers. British Journal of Cancer, 80(9), 1400-1404. DOI:10.1038/sj.bjc.6690535. Publication link: e9fae419-8d03-4aa7-bf18-77a2997d577f
  • Björk-Eriksson, T., West, C., Nilsson, A., Magnusson, B., Svensson, M., Karlsson, E., ... Mercke, C. (1999). The immunohistochemical expression of DNA-PKcs and Ku (p70/p80) in head and neck cancers: relationships with radiosensitivity. International Journal of Radiation Oncology Biology Physics, 45(4), 1005-1010. DOI:10.1016/S0360-3016(99)00268-0. Publication link: e2320e7b-bdf3-4960-8d15-cecc43e4e6b2
  • Cooper, R. A., West, C. M. L., Logue, J. P., Davidson, S. E., Miller, A., Roberts, S., ... Hunter, R. D. (1999). Changes in oxygenation during radiotherapy in carcinoma of the cervix. International Journal of Radiation Oncology Biology Physics, 45(1), 119-126. DOI:10.1016/S0360-3016(99)00093-0. Publication link: b4a69d6a-81a1-471e-8ed5-c15be1882921
  • Cooper, R. A., West, C. M. L., Wilks, D. P., Logue, J. P., Davidson, S. E., Roberts, S. A., & Hunter, R. D. (1999). Tumour vascularity is a significant prognostic factor for cervix carcinoma treated with radiotherapy: Independence from tumour radiosensitivity. British Journal of Cancer, 81(2), 354-358. DOI:10.1038/sj.bjc.6690700. Publication link: c7296c8c-36fd-469a-b3c2-cba92eb77373
  • Eastham, A. M., Marples, B., Kiltie, A. E., Orton, C. J., & West, C. M. L. (1999). Fibroblast radiosensitivity measured using the comet DNA-damage assay correlates with clonogenic survival parameters. British Journal of Cancer, 79(9-10), 1366-1371. . Publication link: f7c07d11-431a-4b4a-889d-00fb991dd18a
  • Kiltie, A. E., Barber, J. B. P., Swindell, R., Ryan, A. J., West, C. M. L., Hendry, J. H., & Magee, B. (1999). Lack of correlation between residual radiation-induced DNA damage, in keratinocytes assayed directly from skin, and late radiotherapy reactions in breast cancer patients. International Journal of Radiation Oncology Biology Physics, 43(3), 481-487. DOI:10.1016/S0360-3016(98)00392-7. Publication link: fc0b9a6f-cf2a-4ff1-bc2a-70a8c901e358
  • Kiltie, A. E., Ryan, A. J., Swindell, R., Barber, J. B. P., West, C. M. L., Magee, B., & Hendry, J. H. (1999). A correlation between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients. Radiotherapy and Oncology, 51(1), 55-65. DOI:10.1016/S0167-8140(99)00030-4. Publication link: 0f33297b-118e-4f5d-a1ab-6a37ba8c1e4c
  • Nishioka, T., West, C. M. L., Gupta, N., Wilks, D. P., Hendry, J. H., Davidson, S. E., & Hunter, R. D. (1999). Prognostic significance of c-erbB-2 protein expression in carcinoma of the cervix treated with radiotherapy. Journal of Cancer Research and Clinical Oncology, 125(2), 96-100. DOI:10.1007/s004320050248. Publication link: 425215f5-2224-458c-9a37-4236e6cbaa71
  • Sheridan, M. T., Cooper, R. A., & West, C. M. L. (1999). A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma. International Journal of Radiation Oncology Biology Physics, 44(3), 507-512. DOI:10.1016/S0360-3016(99)00081-4. Publication link: 640afa15-41fa-4f5b-ab09-4737f20b3b19
  • Slevin, N. J., West, C. M. L., Wilson, G. D., & Hendry, J. H. (1999). The potential benefit from individualised radiotherapy scheduling for head and neck tumours on the basis of both histological grade and kinetics. Radiotherapy and Oncology, 51(2), 109-111. DOI:10.1016/S0167-8140(99)00067-5. Publication link: c5117f04-3d27-46b8-bbf7-aaff5ceb18aa
  • West, C. M. L., Cooper, R. A., Logue, J. P., Davidson, E., Hunter, R. D., Miller, A., ... Stratford, I. J. (1999). Tumour reoxygenation during radiotherapy in carcinoma of the cervix. M&J Radiat, Oncol. Biol. Phys., 45, 119-126. . Publication link: 29419bb1-9b9e-4883-88a3-5ea8b4abb0ad

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