Professor Michael Lisanti MD-PhD

Photograph of Michael Lisanti

Muriel E. Rickman Chair in Breast Oncology

Institute of Cancer Sciences, University of Manchester
Cancer Research UK Manchester Institute, Room RS83, Wilmslow Road, M20 4BX

 

Role

Professor Lisanti serves as the Director of the Manchester Breakthrough Breast Cancer Research Unit and holds the Muriel Edith Rickman Chair of Breast Oncology within the Institute of Cancer Sciences. He is also Professor of Cancer Biology and the new founding Director of the Manchester Centre for Cellular Metabolism (MCCM).

Memberships of Committees and Professional Bodies

American Society for Investigative Pathology (ASIP)

American Association for Cancer Research (AACR)

Research

Recent advances have highlighted the important role of the stroma in breast cancer development. Professor Lisanti’s research programme focuses on the role of Caveolin-1 (Cav-1) in the pathogenesis of human breast cancer, with a strong emphasis on its role in signalling, cancer, metabolism and stem cell biology. Cav-1 status in the stroma provides important information about the aggressiveness of the cancer and may be a valuable and accessible biomarker to predict breast cancer recurrence and metastasis. With the discovery and validation of biomarkers that allow us to identify patients most likely to have poor prognosis, we now have the tools with which to drive the continued development of personalised medicine approaches. These biomarkers will also have a role to play in informing patient selection for clinical trials, allowing new treatments to be tested in patient populations likely to derive the most benefit.

Compartmentalisation of Signal Transduction: The “Caveolae Signalling Hypothesis”. In 1993-94, Dr. Lisanti was among the first to propose that signal transduction takes place in an organized fashion, within lipid rafts and caveolae, which are specialized domains at the cell surface. This mechanism includes G-proteins, Src-like kinases, NOS, and the Ras-MAP kinase signaling, as well as many other pathways. This signalling model was heretical in the early 1990s, and is now well accepted today.

Compartmentalisation of Tumor Metabolism. In 2009, Professor Lisanti was the first to propose the “Reverse Warburg Effect”. This new model for cancer metabolism will facilitate the development of novel diagnostics and therapeutics, driving personalised cancer therapy.

Stromal Cav-1 as a Biomarker: In 2009, Professor Lisanti discovered a new prognostic biomarker, which has now been validated in 8 different countries word-wide for breast cancer. Its prognostic value has also been extended to DCIS lesions (early breast cancers), prostate cancers, and metastatic melanoma, and it may well represent a universal or widely-applicable cancer biomarker for stratified medicine. More specifically, his laboratory has shown that a loss of stromal Cav-1 predicts early tumour recurrence, metastasis, drug-resistance, and overall poor survival in breast cancer patients, at diagnosis, before poor clinical outcome has occurred.

Biography

An active research scientist for more than three decades with a broad background in cell biology and genetics, Professor Lisanti graduated with a degree in Chemistry (Magna Cum Laude) from New York University and obtained his MD-PhD at Cornell University Medical School in Cell Biology and Genetics. From 1992-96, he was a Skeggs Fellow at the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology (MIT), followed by several distinguished appointments at the Albert Einstein College of Medicine and the Kimmel Cancer Center. Professor Lisanti  joined the Breakthrough Unit in 2012 as Professor of Cancer Biology. He is currently listed amongst the Top 100 Most-Cited Researchers in Biochemistry and Biology. He has an H-index >120, with over 50,000 citations. Moreover, he has published > 480 papers and is the former Editor-in-Chief of The American Journal of Pathology.

Qualifications

1981-85       BA in Chemistry, Magna Cum Laude, New York University, New York, USA

1985-92       MD-PhD, Cornell University Tri-Institutional MD-PhD Program (Cornell University, together with Rockefeller University and Memorial Sloan-Kettering), New York, USA

1992-97      Whitehead Institute Fellow, Affiliated with Dr. Harvey Lodish's Laboratory, Whitehead Institute, Massachusetts Institute of Technology (MIT), Boston, USA

Publications

2015

  • Brojatsch, J., Lima, H., Palliser, D., Jacobson, L. S., Muehlbauer, S. M., Furtado, R., ... Chandran, K. (2015). Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents.Cell cycle (Georgetown, Tex.), 14(7). DOI:10.4161/15384101.2014.991194
    . Publication link: 8f2ebff4-18b9-4640-89fb-2bdacca6052b | PubMed:25830414
  • Casaburi, I., Avena, P., De Luca, A., Chimento, A., Sirianni, R., Malivindi, R., ... Pezzi, V. (2015). Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC).Oncotarget, 6(28).
    . Publication link: dab7f38e-b444-4dae-ac2e-2f488c2798ca | PubMed:26312764
  • Casimiro, M. C., Di Sante, G., Crosariol, M., Loro, E., Dampier, W., Ertel, A., ... Pestell, R. G. (2015). Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis.Oncotarget, 6(11).
    . Publication link: 1636acfb-e502-4a8d-b125-e8595ef9d7c6 | PubMed:25940700
  • Casimiro, M. C., Di Sante, G., Ju, X., Li, Z., Chen, K., Crosariol, M., ... Pestell, R. G. (2015). Cyclin D1 promotes androgen-dependent DNA damage repair in prostate cancer cells.Cancer research. DOI:10.1158/0008-5472.CAN-15-0999
    . Publication link: 6b494fc6-972b-4f25-a2e4-f41b195b6f6f | PubMed:26582866
  • Chen, K., Wu, K., Jiao, X., Wang, L., Ju, X., Wang, M., ... Pestell, R. G. (2015). The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module.Cancer research, 75(10). DOI:10.1158/0008-5472.CAN-14-0611
    . Publication link: d872a1b5-f6d3-4c01-bc8e-ddc627b856df | PubMed:25769723
  • Chi, Y., Jasmin, J-F., Seki, Y., Lisanti, M. P., Charron, M. J., Lefer, D. J., & Schuster, V. L. (2015). Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice.PLoS ONE, 10(6). DOI:10.1371/journal.pone.0131735
    . Publication link: 052b43b1-5a47-4b4b-bd1f-d4225ad98024 | PubMed:26121580
  • De Luca, A., Fiorillo, M., Peiris-Pagès, M., Ozsvari, B., Smith, D. L., Sanchez-Alvarez, R., ... Sotgia, F. (2015). Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells.Oncotarget, 6(17).
    . Publication link: 5e5b51a1-86df-4275-b962-ea5f4b83a9cf | PubMed:26087310
  • Di Sante, G., Pestell, T. G., Casimiro, M. C., Bisetto, S., Powell, M. J., Lisanti, M. P., ... Pestell, R. G. (2015). Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria.The American journal of pathology, 185(1). DOI:10.1016/j.ajpath.2014.09.014
    . Publication link: 2d5469c6-3d1b-4fba-a62c-67b948a54bc9 | PubMed:25529796
  • Farnie, G., Sotgia, F., & Lisanti, M. P. (2015). High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant.Oncotarget, 6(31). DOI:10.18632/oncotarget.5401
    . Publication link: 2157abc4-67cf-42f7-b1bd-cd63977976ec | PubMed:26421710
  • Fiorillo, M., Verre, A. F., Iliut, M., Peiris-Pagés, M., Ozsvari, B., Gandara, R., ... Lisanti, M. P. (2015). Graphene oxide selectively targets cancer stem cells, across multiple tumor types: implications for non-toxic cancer treatment, via "differentiation-based nano-therapy".Oncotarget, 6(6).
    . Publication link: 12371fc4-6219-4fbd-b77d-31a7e05f4746 | PubMed:25708684
  • Lamb, R., Bonuccelli, G., Ozsvári, B., Peiris-Pagès, M., Fiorillo, M., Smith, D. L., ... Lisanti, M. P. (2015). Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling.Oncotarget, 6(31). DOI:10.18632/oncotarget.5852
    . Publication link: 0afe11df-f908-4e38-bbc1-9d7be40e4283 | PubMed:26421711
  • Lamb, R., Fiorillo, M., Chadwick, A., Ozsvari, B., Reeves, K. J., Smith, D., ... Lisanti, M. (2015). Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy.Oncotarget, 6(16), 14005-1425. DOI:10.18632/oncotarget.4159
    . Publication link: 8e11e623-b715-469c-a88e-852996a43505 | PubMed:26087309
  • Lamb, R., Harrison, H., Smith, D. L., Townsend, P. A., Jackson, T., Ozsvari, B., ... Sotgia, F. (2015). Targeting tumor-initiating cells: eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction.Oncotarget, 6(7).
    . Publication link: 6caf50b5-6f0b-43fe-8454-43d051b948a8 | PubMed:25671304
  • Lamb, R., Ozsvari, B., Bonuccelli, G., Smith, D. L., Pestell, R. G., Martinez-Outschoorn, U. E., ... Lisanti, M. P. (2015). Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells.Oncotarget, 6(26).
    . Publication link: 41f7db47-9acc-4731-a3c9-f3060eb100f0 | PubMed:26323205
  • Lisanti, M., Lamb, R., Ozsvari, B., Lisanti, C. L., Tanowitz, H. B., Howell, A., ... Lisanti, M. P. (2015). Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease.Oncotarget, 6(7).
    . Publication link: a9a2eb5e-3776-4823-a386-e0b9ff51aaa7 | PubMed:25625193
  • Martinez-Outschoorn, U. E., Sotgia, F., & Lisanti, M. P. (2015). Caveolae and signalling in cancer.Nature reviews. Cancer, 15(4). DOI:10.1038/nrc3915
    . Publication link: e3d8b262-884f-42b7-b8b9-14b588da75de | PubMed:25801618
  • Peiris-Pagès, M., Martinez-Outschoorn, U. E., Sotgia, F., & Lisanti, M. P. (2015). Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?. Cell Metabolism, 22(6). DOI:10.1016/j.cmet.2015.11.008
    . Publication link: 4c2c523a-88de-49a3-86f2-b650871b734c | PubMed:26636492
  • Peiris-Pagès, M., Smith, D. L., Győrffy, B., Sotgia, F., & Lisanti, M. P. (2015). Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts.Aging, 7(10).
    . Publication link: 67d103b3-613d-45bd-9e57-a1950cb3162b | PubMed:26539730
  • Peiris-Pagès, M., Sotgia, F., & Lisanti, M. P. (2015). Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells.Oncotarget, 6(13).
    . Publication link: dfadf447-09d2-4ef8-86f5-a50d9cd08e95 | PubMed:25915429
  • Peiris-Pagès, M., Sotgia, F., & Lisanti, M. P. (2015). Doxycycline and therapeutic targeting of the DNA damage response in cancer cells: old drug, new purpose.Oncoscience, 2(8).
    . Publication link: 76673233-e1ca-4061-b589-918f2b785b1c | PubMed:26425660
  • Ward, R., Sims, A. H., Lee, A., Lo, C., Wynne, L., Yusuf, H., ... Lamb, R. (2015). Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment.Oncotarget, 6(16).
    . Publication link: c9bbedde-4c30-40c1-b567-5d3fdb4d8c9f | PubMed:26008983

2014

  • Bassan, P., Mellor, J., Shapiro, J., Williams, K. J., Lisanti, M. P., Gardner, P., & Lasanti, M. P. (2014). Transmission FT-IR chemical imaging on glass substrates: Applications in infrared spectral histopathology. Analytical Chemistry, 86(3), 1648-1653. DOI:10.1021/ac403412n
    . Publication link: b807767d-962f-438a-bb2a-4c0ac873d978 | PubMed:24410403
  • Ju, X., Casimiro, M. C., Gormley, M., Meng, H., Jiao, X., Katiyar, S., ... Pestell, R. G. (2014). Identification of a cyclin D1 network in prostate cancer that antagonizes epithelial-mesenchymal restraint.Cancer research, 74(2). DOI:10.1158/0008-5472.CAN-13-1313
    . Publication link: 28574272-056c-4349-ab1e-2768d7f855b0 | PubMed:24282282
  • Lamb, R., Harrison, H., Hulit, J., Smith, D. L., Lisanti, M. P., & Sotgia, F. (2014). Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition.Oncotarget, 5(22).
    . Publication link: 6fdc130a-f484-4113-a80c-6e08f2034366 | PubMed:25415228
  • Lamb, R., Lisanti, M. P., Clarke, R. B., & Landberg, G. (2014). Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer. Oncotarget, 5(17), 7833-7842.
    . Publication link: 6c524989-dc3e-4cc5-9bdb-330dc4a9576c
  • Lamb, R., Lisanti, M. P., Clarke, R. B., & Landberg, G. (2014). Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer.Oncotarget, 5(17).
    . Publication link: be41c201-09d8-43d9-be37-49a0d3dda025 | PubMed:25277201
  • Li, Z., Chen, K., Jiao, X., Wang, C., Willmarth, N. E., Casimiro, M. C., ... Pestell, R. G. (2014). Cyclin D1 integrates estrogen-mediated DNA damage repair signaling.Cancer research, 74(14). DOI:10.1158/0008-5472.CAN-13-3137
    . Publication link: 0c318d61-e1c5-4e95-96de-0d895cb4f431 | PubMed:24830723
  • Martinez-Outschoorn, U. E., Lisanti, M. P., & Sotgia, F. (2014). Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth.Seminars in cancer biology, 25. DOI:10.1016/j.semcancer.2014.01.005
    . Publication link: 33624131-5bc9-4269-b9b6-a04dacd4e9e7 | PubMed:24486645
  • Martinez-Outschoorn, U. E., Sotgia, F., & Lisanti, M. P. (2014). Metabolic asymmetry in cancer: a "balancing act" that promotes tumor growth.Cancer cell, 26(1). DOI:10.1016/j.ccr.2014.06.021
    . Publication link: c1162773-dcb2-4bbb-a1cc-b2bc3c33932a | PubMed:25026205
  • Martinez-Outschoorn, U., Sotgia, F., & Lisanti, M. P. (2014). Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function.Seminars in oncology, 41(2). DOI:10.1053/j.seminoncol.2014.03.002
    . Publication link: 715ac15a-d08d-4d2b-95c3-998fa259fbb1 | PubMed:24787293
  • Mercier, I., Gonzales, D. M., Quann, K., Pestell, T. G., Molchansky, A., Sotgia, F., ... Jasmin, J-F. (2014). CAPER, a novel regulator of human breast cancer progression.Cell cycle (Georgetown, Tex.), 13(8). DOI:10.4161/cc.28156
    . Publication link: 184d3935-e6f7-47d5-8e0c-003f95c933bc | PubMed:24621503
  • Pavlides, S., Gutierrez-Pajares, J. L., Iturrieta, J., Lisanti, M. P., & Frank, P. G. (2014). Endothelial caveolin-1 plays a major role in the development of atherosclerosis.Cell and Tissue Research, 356(1). DOI:10.1007/s00441-013-1767-7
    . Publication link: 4f89babe-82cd-42b9-a33a-20d5ec1373b8 | PubMed:24390341
  • Pavlides, S., Gutierrez-Pajares, J. L., Katiyar, S., Jasmin, J-F., Mercier, I., Walters, R., ... Frank, P. G. (2014). Caveolin-1 regulates the anti-atherogenic properties of macrophages.Cell and Tissue Research, 358(3). DOI:10.1007/s00441-014-2008-4
    . Publication link: 7718d05d-96ba-4918-abba-2fa35fe40928 | PubMed:25322709
  • Peiris Pages, M., Lisanti, M. P., Tsirigos, A., Pavlides, S., Reeves, K. J., Peiris-Pagès, M., ... Sotgia, F. (2014). JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: connecting fibrosis, inflammation, and stemness for cancer prevention.Cell cycle (Georgetown, Tex.), 13(4), 580-599. DOI:10.4161/cc.27379
    . Publication link: 7b53ced3-abeb-464a-8992-9aacdeb0be34 | PubMed:24434780
  • Sicoli, D., Jiao, X., Ju, X., Velasco-Velazquez, M., Ertel, A., Addya, S., ... Pestell, R. G. (2014). CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines.Cancer research, 74(23). DOI:10.1158/0008-5472.CAN-14-0612
    . Publication link: 684ba0fb-376f-4f1b-9b22-7d6a66587dd9 | PubMed:25452256
  • Wright, P. K., Jones, S. B., Ardern, N., Ward, R., Clarke, R. B., Sotgia, F., ... Lamb, R. (2014). 17β-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells. Oncotarget, 5(10), 3055-3065.
    . Publication link: 06ed0d17-2cff-4324-b171-3dd750c7e62c
  • Wright, P. K., Jones, S. B., Ardern, N., Ward, R., Clarke, R. B., Sotgia, F., ... Lamb, R. (2014). 17β-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells.Oncotarget, 5(10).
    . Publication link: 87350171-c181-457e-a843-3bb4ff2385ad | PubMed:24931391
  • Wu, K., Chen, K., Wang, C., Jiao, X., Wang, L., Zhou, J., ... Pestell, R. G. (2014). Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation.Cancer research, 74(3). DOI:10.1158/0008-5472.CAN-13-2466
    . Publication link: 0d0999b3-edce-49ab-900c-1d6eee5c15a5 | PubMed:24335958

2013

  • Al-Zoubi, M., Salem, A. F., Martinez-Outschoorn, U. E., Whitaker-Menezes, D., Lamb, R., Hulit, J., ... Lisanti, M. P. (2013). Creating a tumor-resistant microenvironment Cell-mediated delivery of TNFα completely prevents breast cancer tumor formation in vivo. Cell Cycle, 12(3), 480-490. DOI:10.4161/cc.23370
    . Publication link: 8c555bef-f8f4-400f-8b91-503ccea4f70c | PubMed:23292149
  • Araujo, K. P. C., Bonuccelli, G., Duarte, C. N., Gaiad, T. P., Moreira, D. F., Feder, D., ... Ambrosio, C. E. (2013). Bortezomib (PS-341) Treatment Decreases Inflammation and Partially Rescues the Expression of the Dystrophin-Glycoprotein Complex in GRMD Dogs. PLoS ONE, 8(4), [e61367]. DOI:10.1371/journal.pone.0061367
    . Publication link: dc757555-ce2d-4c67-8547-76e7241dcac7 | PubMed:23579193
  • Avena, P., Anselmo, W., Whitaker-Menezes, D., Wang, C., Pestell, R. G., Lamb, R. S., ... Sotgia, F. (2013). Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis. Cell Cycle, 12(9), 1360-1370. DOI:10.4161/cc.24289
    . Publication link: 2e25641e-0953-4e71-b9d8-515f4518438a | PubMed:23574724
  • Ayala, G., Morello, M., Frolov, A., You, S., Li, R., Rosati, F., ... Di Vizio, D. (2013). Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression. Journal of Pathology, 231(1), 77-87. DOI:10.1002/path.4217
    . Publication link: 1893c9da-eb76-4e3d-8cf1-bdbf6c35c6c1 | PubMed:23729330
  • Casimiro, M. C., Wang, C., Li, Z., Di Sante, G., Willmart, N. E., Addya, S., ... Pestell, R. G. (2013). Cyclin D1 determines estrogen signaling in the mammary gland in vivo.Molecular endocrinology (Baltimore, Md.), 27(9). DOI:10.1210/me.2013-1065
    . Publication link: 1a8168ff-1a4c-4928-98a3-2b5c5711d624 | PubMed:23864650
  • Chadwick, A. L., Howell, A., Sotgia, F., & Lisanti, M. P. (2013). Carbonic anhydrase 9 (CA9) and redox signaling in cancer-associated fibroblasts: Therapeutic implications. Cell Cycle, 12(16), 2534. DOI:10.4161/cc.25842
    . Publication link: 06d89a83-eda7-419f-884f-6b21d7584f85 | PubMed:23907127
  • Champ, C. E., Baserga, R., Mishra, M. V., Jin, L., Sotgia, F., Lisanti, M. P., ... Simone, N. L. (2013). Nutrient restriction and radiation therapy for cancer treatment: When less is more. Oncologist, 18(1), 97-103. DOI:10.1634/theoncologist.2012-0164
    . Publication link: fe79302e-ef73-410e-8648-9634ccc8d878 | PubMed:23299773
  • Chen, K., Wu, K., Cai, S., Zhang, W., Zhou, J., Wang, J., ... Pestell, R. G. (2013). Dachshund binds p53 to block the growth of lung adenocarcinoma cells. Cancer Research, 73(11), 3262-3274. DOI:10.1158/0008-5472.CAN-12-3191
    . Publication link: 45af0904-f68e-40e9-823f-ae6f758fdae2 | PubMed:23492369
  • Chen, K., Wu, K., Gormley, M., Ertel, A., Wang, J., Zhang, W., ... Pestell, R. G. (2013). Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer.Oncotarget, 4(6), 923-935.
    . Publication link: 75a14c8d-b614-49d1-a332-e7e07c782895 | PubMed:23798621
  • Curry, J. M., Tuluc, M., Whitaker-Menezes, D., Ames, J. A., Anantharaman, A., Butera, A., ... Martinez-Outschoorn, U. E. (2013). Cancer metabolism, stemness and tumor recurrence : MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer. Cell Cycle, 12(9), 1371-1384. DOI:10.4161/cc.24092
    . Publication link: 1a9f80b4-41a4-47df-b0bb-47dba550980e | PubMed:23574725
  • Danilo, C., Gutierrez-Pajares, J. L., Mainieri, M. A., Mercier, I., Lisanti, M. P., & Frank, P. G. (2013). Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development.Breast cancer research : BCR, 15(5). DOI:10.1186/bcr3483
    . Publication link: fa1d0b34-15f2-4915-a602-be4fb0ee8cf3 | PubMed:24060386
  • De Almeida, C. J. G., Jasmin, J. F., Del Galdo, F., & Lisanti, M. P. (2013). Genetic ablation of caveolin-2 sensitizes mice to bleomycin-induced injury. Cell Cycle, 12(14), 2248-2254. DOI:10.4161/cc.25335
    . Publication link: ac7f4ab8-b691-49ef-9aa3-308bde806675 | PubMed:23797586
  • Jelicks, L. A., Lisanti, M. P., MacHado, F. S., Weiss, L. M., Tanowitz, H. B., & Desruisseaux, M. S. (2013). Imaging of small-animal models of infectious diseases. American Journal of Pathology, 182(2), 296-304. DOI:10.1016/j.ajpath.2012.09.026
    . Publication link: f95c8dde-71a8-4193-9878-02cdd10f4f83 | PubMed:23201133
  • Ju, X., Ertel, A., Casimiro, M. C., Yu, Z., Meng, H., McCue, P. A., ... Pestell, R. G. (2013). Novel oncogene-induced metastatic prostate cancer cell lines define human prostate cancer progression signatures. Cancer Research, 73(2), 978-989. DOI:10.1158/0008-5472.CAN-12-2133
    . Publication link: 3b70412d-154d-472c-baac-1f5530048670 | PubMed:23204233
  • Li, Z., Wermuth, P. J., Benn, B. S., Lisanti, M. P., & Jimenez, S. A. (2013). Caveolin-1 deficiency induces spontaneous endothelial-to-mesenchymal transition in murine pulmonary endothelial cells in vitro. American Journal of Pathology, 182(2), 325-331. DOI:10.1016/j.ajpath.2012.10.022
    . Publication link: 0a2c2667-76bc-48eb-b0b0-117ab22dc1ed | PubMed:23195429
  • Lima, H., Jacobson, L. S., Goldberg, M. F., Chandran, K., Diaz-Griffero, F., Lisanti, M. P., & Brojatsch, J. (2013). Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death.Cell cycle (Georgetown, Tex.), 12(12), 1868-1878. DOI:10.4161/cc.24903
    . Publication link: 9ca03b34-4c86-4b68-b8e5-3098c981faf1 | PubMed:23708522
  • Lisanti, M. P., Martinez-Outschoorn, U. E., & Sotgia, F. (2013). Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery. Cell Cycle, 12(17), 2723-2732. DOI:10.4161/cc.25695
    . Publication link: 5d3681b8-710c-4daf-bd25-320bf09ef817 | PubMed:23860382
  • Lisanti, M. P., Sotgia, F., Pestell, R. G., Howell, A., & Martinez-Outschoorn, U. E. (2013). Stromal glycolysis and MCT4 are hallmarks of DCIS progression to invasive breast cancer.Cell cycle (Georgetown, Tex.), 12(18), 2935-2936. DOI:10.4161/cc.26280
    . Publication link: 0cdb842e-88b9-4b9a-af69-2f5791bde043 | PubMed:23989616
  • Lisanti, M., Trimmer, C., & Capozza, F. (2013). Cav1 inhibits benign skin tumor development in a two-stage carcinogenesis model by suppressing epidermal proliferation. American Journal of Translational Research, 5(1), 80-91.
    . Publication link: fb7b2b6e-8ef4-4969-8b39-a79fb3157e9f | PubMed:23390568
  • Martinez-Outschoorn, U. E., Curry, J. M., Ko, Y-H., Lin, Z., Tuluc, M., Cognetti, D., ... Lisanti, M. P. (2013). Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4.Cell cycle (Georgetown, Tex.), 12(16). DOI:10.4161/cc.25510
    . Publication link: c866c51c-b681-4092-b9af-a9fc0ba1298b | PubMed:23860378
  • Martinez-Outschoorn, U. E., Whitaker-Menezes, D., Valsecchi, M., Martinez-Cantarin, M. P., Dulau-Florea, A., Gong, J., ... Lisanti, M. P. (2013). Reverse warburg effect in a patient with aggressive B-cell lymphoma: Is lactic acidosis a paraneoplastic syndrome?. Seminars in Oncology, 40(4), 403-418. DOI:10.1053/j.seminoncol.2013.04.016
    . Publication link: 9256e347-01cd-41b1-91ad-58e36d3a0dac | PubMed:23972703
  • Mukherjee, S., Sadekar, N., Ashton, A. W., Huang, H., Spray, D. C., Lisanti, M. P., ... Tanowitz, H. B. (2013). Identification of a functional prostanoid-like receptor in the protozoan parasite, Trypanosoma cruzi. Parasitology Research, 112(4), 1417-1425. DOI:10.1007/s00436-012-3271-5
    . Publication link: d57346e4-5392-4f67-9a6e-c356e4014a1d | PubMed:23403991
  • Nagajyothi, F., Kuliawat, R., Kusminski, C. M., Machado, F. S., Desruisseaux, M. S., Zhao, D., ... Tanowitz, H. B. (2013). Alterations in glucose homeostasis in a murine model of Chagas disease. American Journal of Pathology, 182(3), 886-894. DOI:10.1016/j.ajpath.2012.11.027
    . Publication link: 89ab5c9d-9bd2-4f41-abbe-10730daabc26 | PubMed:23321322
  • Quann, K., Gonzales, D. M., Mercier, I., Wang, C., Sotgia, F., Pestell, R. G., ... Jasmin, J. F. (2013). Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide. Cell Cycle, 12(10), 1510-1520. DOI:10.4161/cc.24497
    . Publication link: 1acd6eba-c926-4b8f-bfd6-4a2e92cd4166 | PubMed:23598719
  • Saleh, A. D., Simone, B. A., Palazzo, J., Savage, J. E., Sano, Y., Dan, T., ... Simone, N. L. (2013). Caloric restriction augments radiation efficacy in breast cancer. Cell Cycle, 12(12), 1955-1963. DOI:10.4161/cc.25016
    . Publication link: 47cc55cc-f4bd-4d82-b965-61552f050763 | PubMed:23708519
  • Salem, A. F., Al-Zoubi, M. S., Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Lamb, R., Hulit, J., ... Lisanti, M. P. (2013). Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment. Cell Cycle, 12(5), 818-825. DOI:10.4161/cc.23722
    . Publication link: ef8650dd-d7ad-44a0-8f90-df5dccdfd7d3 | PubMed:23388463
  • Sanchez-Alvarez, R., Martinez-Outschoorn, U. E., Lamb, R., Hulit, J., Howell, A., Gandara, R., ... Sotgia, F. (2013). Mitochondrial dysfunction in breast cancer cells prevents tumor growth: Understanding chemoprevention with metformin. Cell Cycle, 12(1), 172-182. DOI:10.4161/cc.23058
    . Publication link: 5fb85e5a-dcee-4cdc-b7b2-f57e9122c54d | PubMed:23257779
  • Sanchez-Alvarez, R., Martinez-Outschoorn, U. E., Lin, Z., Lamb, R., Hulit, J., Howell, A., ... Lisanti, M. P. (2013). Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism: implications for breast cancer prevention.Cell cycle (Georgetown, Tex.), 12(2), 289-301. DOI:10.4161/cc.23109
    . Publication link: d6e4917d-73c7-428c-9b74-36ba9e98276e | PubMed:23257780
  • Sotgia, F., Martinez-Outschoorn, U. E., & Lisanti, M. P. (2013). Cancer metabolism: New validated targets for drug discovery. Oncotarget, 4(8), 1309-1316.
    . Publication link: 08271651-b41d-45ab-af7f-a5ff2b5d6356 | PubMed:23896568
  • Suk, H. Y., Zhou, C., Yang, T. T. C., Zhu, H., Yu, R. Y. L., Olabisi, O., ... Chow, C. W. (2013). Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases. Journal of Biological Chemistry, 288(5), 3477-3488. DOI:10.1074/jbc.M112.419150
    . Publication link: 1c916116-06ae-4df8-9806-950a833a9f14 | PubMed:23258544
  • Trimmer, C., Bonuccelli, G., Katiyar, S., Sotgia, F., Pestell, R. G., Lisanti, M. P., & Capozza, F. (2013). Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activation. American Journal of Pathology, 182(3), 992-1004. DOI:10.1016/j.ajpath.2012.11.008
    . Publication link: 68d0b2d4-5a8d-4168-8d61-440425c75328 | PubMed:23267770
  • Volonte, D., Liu, Z., Musille, P. M., Stoppani, E., Wakabayashi, N., Di, Y. P., ... Galbiati, F. (2013). Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence. Molecular Biology of the Cell, 24(12), 1852-1862. DOI:10.1091/mbc.E12-09-0666
    . Publication link: 5e292b55-ea86-4753-9bd9-9b67353c59f3 | PubMed:23637463

2012

  • Bonuccelli, G., Castello-Cros, R., Capozza, F., Martinez-Outschoorn, U. E., Lin, Z., Tsirigos, A., ... Sotgia, F. (2012). The milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis. Cell Cycle, 11(21), 3972-3982. DOI:10.4161/cc.22227
    . Publication link: d1c8b6b4-3fe7-4ae3-89a3-4eadfcb45f43 | PubMed:23047602
  • Capozza, F., Trimmer, C., Castello-Cros, R., Katiyar, S., Whitaker-Menezes, D., Follenzi, A., ... Lisanti, M. P. (2012). Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: Role of Cav1 in Shh heterotypic signaling and transendothelial migration. Cancer Research, 72(9), 2262-2274. DOI:10.1158/0008-5472.CAN-11-2593
    . Publication link: f178ff7e-5624-4e88-9f16-8ce3108fbe3f | PubMed:22396494
  • Capparelli, C., Chiavarina, B., Whitaker-Menezes, D., Pestell, T. G., Pestell, R. G., Hulit, J., ... Lisanti, M. P. (2012). CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle, 11(19), 3599-3610. DOI:10.4161/cc.21884
    . Publication link: d02b98a1-521e-4ee2-8671-f116a5f6ceb9 | PubMed:22935696
  • Capparelli, C., Guido, C., Whitaker-Menezes, D., Bonuccelli, G., Balliet, R., Pestell, T. G., ... Lisanti, M. P. (2012). Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production. Cell Cycle, 11(12), 2285-2302. DOI:10.4161/cc.20718
    . Publication link: 52ac4f61-9e11-4a5f-8162-60933e248b69 | PubMed:22684298
  • Capparelli, C., Whitaker-Menezes, D., Guido, C., Balliet, R., Pestell, T. G., Howell, A., ... Sotgia, F. (2012). CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle, 11(12), 2272-2284. DOI:10.4161/cc.20717
    . Publication link: d9ae7663-ac9f-438d-b477-f0a7060d7034 | PubMed:22684333
  • Carito, V., Bonuccelli, G., Martinez-Outschoorn, U. E., Whitaker-Menezes, D., Caroleo, M. C., Cione, E., ... Sotgia, F. (2012). Metabolic remodeling of the tumor microenvironment: Migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth. Cell Cycle, 11(18), 3403-3414. DOI:10.4161/cc.21701
    . Publication link: 5c2056e1-70a9-488e-b950-6ab6d20c49ba | PubMed:22918248
  • Chiavarina, B., Martinez-Outschoorn, U. E., Whitaker-Menezes, D., Howell, A., Tanowitz, H. B., Pestell, R. G., ... Lisanti, M. P. (2012). Metabolic reprogramming and two-compartment tumor metabolism: Opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells. Cell Cycle, 11(17), 3280-3289. DOI:10.4161/cc.21643
    . Publication link: 5972897d-61c9-4f09-afcf-7cf28da5dc50 | PubMed:22894905
  • Di Vizio, D., Morello, M., Dudley, A. C., Schow, P. W., Adam, R. M., Morley, S., ... Freeman, M. R. (2012). Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease. American Journal of Pathology, 181(5), 1573-1584. DOI:10.1016/j.ajpath.2012.07.030
    . Publication link: 755539bf-ab22-4ed4-8eac-7c2b475050a0 | PubMed:23022210
  • Ertel, A., Tsirigos, A., Whitaker-Menezes, D., Birbe, R. C., Pavlides, S., Martinez-Outschoorn, U. E., ... Lisanti, M. P. (2012). Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism. Cell Cycle, 11(2), 253-263. DOI:10.4161/cc.11.2.19006
    . Publication link: f4a724bb-9ee5-4c7a-b8bd-b981cf41e7c7 | PubMed:22234241
  • Esper, L., Roman-Campos, D., Lara, A., Brant, F., Castro, L. L., Barroso, A., ... Machado, F. S. (2012). Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease. American Journal of Pathology, 181(1), 130-140. DOI:10.1016/j.ajpath.2012.03.042
    . Publication link: 740f2d5a-69c6-47a3-932a-c795341f3bdf | PubMed:22658486
  • Gazzerro, E., Baldassari, S., Giacomini, C., Musante, V., Fruscione, F., la Padula, V., ... Minetti, C. (2012). Hyccin, the molecule mutated in the leukodystrophy hypomyelination and congenital cataract (HCC), is a neuronal protein. PLoS ONE, 7(3), [e32180]. DOI:10.1371/journal.pone.0032180
    . Publication link: f369d5a9-9bb9-4adb-9cbd-679b7b4b6aed | PubMed:22461884
  • Guido, C., Panza, S., Santoro, M., Avena, P., Panno, M. L., Perrotta, I., ... Aquila, S. (2012). Estrogen receptor β (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle, 11(15), 2911-2921. DOI:10.4161/cc.21336
    . Publication link: f143aecb-b99f-44ee-ae83-7c1d775a47b3 | PubMed:22810004
  • Guido, C., Whitaker-Menezes, D., Capparelli, C., Balliet, R., Lin, Z., Pestell, R. G., ... Lisanti, M. P. (2012). Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with "Warburg- like" cancer metabolism and L-lactate production. Cell Cycle, 11(16), 3019-3035. DOI:10.4161/cc.21384
    . Publication link: 0afa438c-6ceb-4740-8338-615646e1bc04 | PubMed:22874531
  • Guido, C., Whitaker-Menezes, D., Lin, Z., Pestell, R. G., Howell, A., Zimmers, T. A., ... Lisanti, M. P. (2012). Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth. Oncotarget, 3(8), 798-810.
    . Publication link: 7d16d479-4cca-4c6b-9202-df47a925017d | PubMed:22878233
  • Katiyar, S., Jiao, X., Addya, S., Ertel, A., Covarrubias, Y., Rose, V., ... Pestell, R. G. (2012). Mammary gland selective excision of c-Jun identifies its role in mRNA splicing. Cancer Research, 72(4), 1023-1034. DOI:10.1158/0008-5472.CAN-11-3647
    . Publication link: 1478030c-9eb4-42d5-8f7c-0accf44f43ee | PubMed:22174367
  • Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., ... Zuckerbraun, B. (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), 445-544. DOI:10.4161/auto.19496
    . Publication link: b687be3d-5d7b-4d3a-a9eb-01db4a8e27ca | PubMed:22966490
  • MacHado, F. S., Rodriguez, N. E., Adesse, D., Garzoni, L. R., Esper, L., Lisanti, M. P., ... Tanowitz, H. B. (2012). Recent developments in the interactions between caveolin and pathogens. Advances in Experimental Medicine and Biology, 729, 65-82. DOI:10.1007/978-1-4614-1222-9_5
    . Publication link: c15ab9b7-1dff-4948-9f55-b8b1df7cd1a6 | PubMed:22411314
  • Martinez-Outschoorn, U. E., Balliet, R. M., Lin, Z., Whitaker-Menezes, D., Howell, A., Sotgia, F., & Lisanti, M. P. (2012). Hereditary ovarian cancer and two-compartment tumor metabolism: Epithelial loss of BRCA1 induces hydrogen peroxide production, driving oxidative stress and NFκB activation in the tumor stroma. Cell Cycle, 11(22), 4152-4166. DOI:10.4161/cc.22226
    . Publication link: 980e0495-3bec-4007-93b4-28bfd2fe08a0 | PubMed:23047606
  • Martinez-Outschoorn, U. E., Balliet, R., Lin, Z., Whitaker-Menezes, D., Birbe, R. C., Bombonati, A., ... Lisanti, M. P. (2012). BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: Implications for breast cancer prevention with antioxidant therapies. Cell Cycle, 11(23), 4402-4413. DOI:10.4161/cc.22776
    . Publication link: 5782e270-cb6e-4e81-9995-8a12b3f2b13b | PubMed:23172369
  • Martinez-Outschoorn, U. E., Lin, Z., Whitaker-Menezes, D., Howell, A., Lisanti, M. P., & Sotgia, F. (2012). Ketone bodies and two-compartment tumor metabolism: Stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells. Cell Cycle, 11(21), 3956-3963. DOI:10.4161/cc.22136
    . Publication link: 1272c709-2e7f-4210-8d86-47b52808ea60 | PubMed:23082721
  • Martinez-Outschoorn, U. E., Lin, Z., Whitaker-Menezes, D., Howell, A., Sotgia, F., & Lisanti, M. P. (2012). Ketone body utilization drives tumor growth and metastasis. Cell Cycle, 11(21), 3964-3971. DOI:10.4161/cc.22137
    . Publication link: 97d8cd80-af23-454b-acff-7a2956c83dd9 | PubMed:23082722
  • Martinez-Outschoorn, U. E., Sotgia, F., & Lisanti, M. P. (2012). Power surge: Supporting cells "fuel" cancer cell mitochondria. Cell Metabolism, 15(1), 4-5. DOI:10.1016/j.cmet.2011.12.011
    . Publication link: 391d4634-868b-44b2-bb11-5d6d80eeb027 | PubMed:22225869
  • Mercier, I., & Lisanti, M. P. (2012). Caveolin-1 and breast cancer: A new clinical perspective. Advances in Experimental Medicine and Biology, 729, 83-94. DOI:10.1007/978-1-4614-1222-9_6
    . Publication link: ea4217e8-0868-4ff9-9797-19f9d4cf930d | PubMed:22411315
  • Mercier, I., Camacho, J., Titchen, K., Gonzales, D. M., Quann, K., Bryant, K. G., ... Lisanti, M. P. (2012). Caveolin-1 and accelerated host aging in the breast tumor microenvironment: Chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug. American Journal of Pathology, 181(1), 278-293. DOI:10.1016/j.ajpath.2012.03.017
    . Publication link: b11bc211-ddb6-48a7-b737-280f7567083c | PubMed:22698676
  • Nagajyothi, F., Desruisseaux, M. S., MacHado, F. S., Upadhya, R., Zhao, D., Schwartz, G. J., ... Tanowitz, H. B. (2012). Response of adipose tissue to early infection with trypanosoma cruzi (Brazil Strain). Journal of Infectious Diseases, 205(5), 830-840. DOI:10.1093/infdis/jir840
    . Publication link: 36835c2e-ff74-4246-bac1-85466cd7f495 | PubMed:22293433
  • Nagajyothi, F., Machado, F. S., Burleigh, B. A., Jelicks, L. A., Scherer, P. E., Mukherjee, S., ... Tanowitz, H. B. (2012). Mechanisms of Trypanosoma cruzi persistence in Chagas disease. Cellular Microbiology, 14(5), 634-643. DOI:10.1111/j.1462-5822.2012.01764.x
    . Publication link: 4f7d451c-a0d6-45e9-8fd9-950ce185b662 | PubMed:22309180
  • Neill, T., Painter, H., Buraschi, S., Owens, R. T., Lisanti, M. P., Schaefer, L., & Iozzo, R. V. (2012). Decorin antagonizes the angiogenic network: Concurrent inhibition of met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and tiMP3. Journal of Biological Chemistry, 287(8), 5492-5506. DOI:10.1074/jbc.M111.283499
    . Publication link: 4e8317cb-17b7-4a10-b5a1-f3c50251f0de | PubMed:22194599
  • Ørom, U. A., Lim, M. K., Savage, J. E., Jin, L., Saleh, A. D., Lisanti, M. P., & Simone, N. L. (2012). MicroRNA-203 regulates caveolin-1 in breast tissue during caloric restriction. Cell Cycle, 11(7), 1291-1295. DOI:10.4161/cc.19704
    . Publication link: a1d44544-db4b-4117-9d73-7bd5baaed4d3 | PubMed:22421148
  • Pavlides, S., Gutierrez-Pajares, J. L., Danilo, C., Lisanti, M. P., & Frank, P. G. (2012). Atherosclerosis, caveolae and caveolin-1. Advances in Experimental Medicine and Biology, 729, 127-144. DOI:10.1007/978-1-4614-1222-9_9
    . Publication link: f8e2b5e0-c353-43d5-8756-446373379b30 | PubMed:22411318
  • Pavlides, S., Vera, I., Gandara, R., Sneddon, S., Pestell, R. G., Mercier, I., ... Lisanti, M. P. (2012). Warburg meets autophagy: Cancer-Associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis. Antioxidants and Redox Signaling, 16(11), 1264-1284. DOI:10.1089/ars.2011.4243
    . Publication link: 77c64c68-677a-4b77-aca8-cdd50f7952d0 | PubMed:21883043
  • Salem, A. F., Howell, A., Sartini, M., Sotgia, F., & Lisanti, M. P. (2012). Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production. Cell Cycle, 11(22), 4167-4173. DOI:10.4161/cc.22316
    . Publication link: 7630df26-27b7-4c37-920e-974c1a5add84 | PubMed:23047605
  • Salem, A. F., Whitaker-Menezes, D., Howell, A., Sotgia, F., & Lisanti, M. P. (2012). Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance. Cell Cycle, 11(22), 4174-4180. DOI:10.4161/cc.22376
    . Publication link: 10e44f84-faf8-4c31-85ed-6442ab841ec6 | PubMed:23070475
  • Salem, A. F., Whitaker-Menezes, D., Lin, Z., Martinez-Outschoorn, U. E., Tanowitz, H. B., Al-Zoubi, M. S., ... Lisanti, M. P. (2012). Two-compartment tumor metabolism: Autophagy in the tumor microenvironment, and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. Cell Cycle, 11(13), 2545-2556. DOI:10.4161/cc.20920
    . Publication link: 889378fb-5a23-45de-b0ca-1c8c1a241d71 | PubMed:22722266
  • Shikani, H. J., Freeman, B. D., Lisanti, M. P., Weiss, L. M., Tanowitz, H. B., & Desruisseaux, M. S. (2012). Cerebral malaria: We have come a long way. American Journal of Pathology, 181(5), 1484-1492. DOI:10.1016/j.ajpath.2012.08.010
    . Publication link: c4303eec-b255-4baa-a47a-68e9c77abfb6 | PubMed:23021981
  • Sirajuddin, P., Das, S., Ringer, L., Rodriguez, O. C., Sivakumar, A., Lee, Y. C., ... Albanese, C. (2012). Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI. Cell Cycle, 11(20), 3801-3809. DOI:10.4161/cc.21988
    . Publication link: fa9655cb-aae5-49fd-8408-9daaaf8641c9 | PubMed:22983062
  • Sotgia, F., Martinez-Outschoorn, U. E., Howell, A., Pestell, R. G., Pavlides, S., & Lisanti, M. P. (2012). Caveolin-1 and cancer metabolism in the tumor microenvironment: Markers, models, and mechanisms. Annual Review of Pathology: Mechanisms of Disease, 7, 423-467. DOI:10.1146/annurev-pathol-011811-120856
    . Publication link: f17d42bb-22f9-4457-80c6-317d3dae45c3 | PubMed:22077552
  • Sotgia, F., Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Flomenberg, N., Birbe, R. C., Witkiewicz, A. K., ... Lisanti, M. P. (2012). Mitochondrial metabolism in cancer metastasis: Visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue. Cell Cycle, 11(7), 1445-1454. DOI:10.4161/cc.19841
    . Publication link: d74d6760-1a7a-4200-bc3b-c1b919f19fa1 | PubMed:22395432
  • Sotgia, F., Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Salem, A. F., Tsirigos, A., Lamb, R., ... Lisanti, M. P. (2012). Mitochondria "fuel" breast cancer metabolism: Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. Cell Cycle, 11(23), 4390-4401. DOI:10.4161/cc.22777
    . Publication link: 8beb2fd4-5b22-4674-a25b-a2d826f93d90 | PubMed:23172368
  • Tsai, E. J., Liu, Y., Koitabashi, N., Bedja, D., Danner, T., Jasmin, J. F., ... Kass, D. A. (2012). Pressure-overload-induced subcellular relocalization/oxidation of soluble guanylyl cyclase in the heart modulates enzyme stimulation. Circulation Research, 110(2), 295-303. DOI:10.1161/CIRCRESAHA.111.259242
    . Publication link: 13de83a8-3902-4721-839a-fd8b58f9ff73 | PubMed:22095726
  • Velasco-Velázquez, M., Jiao, X., De La Fuente, M., Pestell, T. G., Ertel, A., Lisanti, M. P., & Pestell, R. G. (2012). CCR5 antagonist blocks metastasis of basal breast cancer cells. Cancer Research, 72(15), 3839-3850. DOI:10.1158/0008-5472.CAN-11-3917
    . Publication link: 4696fb04-1aee-4b25-8c28-2db5448f9193 | PubMed:22637726
  • Wang, Y., Wang, X., Jasmin, J. F., Lau, W. B., Li, R., Yuan, Y., ... Ma, X. L. (2012). Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(4), 934-942. DOI:10.1161/ATVBAHA.111.242164
    . Publication link: b9a1be04-098d-4578-b361-2c7181c7cf85 | PubMed:22328772
  • Witkiewicz, A. K., Whitaker-Menezes, D., Dasgupta, A., Philp, N. J., Lin, Z., Gandara, R., ... Lisanti, M. P. (2012). Using the "reverse Warburg effect" to identify high-risk breast cancer patients: Stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers. Cell Cycle, 11(6), 1108-1117. DOI:10.4161/cc.11.6.19530
    . Publication link: e781eeb1-7e39-4d7d-82fb-cce9edb93eac | PubMed:22313602
  • Yu, Z., Pestell, T. G., Lisanti, M. P., & Pestell, R. G. (2012). Cancer stem cells. International Journal of Biochemistry and Cell Biology, 44(12), 2144-2151. DOI:10.1016/j.biocel.2012.08.022
    . Publication link: 5568a1f7-4cc8-493b-9dd1-5c1ad7f20971 | PubMed:22981632

2011

  • Balliet, R. M., Capparelli, C., Guido, C., Pestell, T. G., Martinez-Outschoorn, U. E., Lin, Z., ... Lisanti, M. P. (2011). Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: Understanding the aging and cancer connection. Cell Cycle, 10(23), 4065-4073. DOI:10.4161/cc.10.23.18254
    . Publication link: 7aba73a8-17b2-4a6e-b8b5-ae97f56a77d7 | PubMed:22129993
  • Bryant, K. G., Camacho, J., Jasmin, J. F., Wang, C., Addya, S., Casimiro, M. C., ... Mercier, I. (2011). Caveolin-1 overexpression enhances androgen-dependent growth and proliferation in the mouse prostate. International Journal of Biochemistry and Cell Biology, 43(9), 1318-1329. DOI:10.1016/j.biocel.2011.04.019
    . Publication link: ebba527f-c3e4-4d66-8580-2769bd2c77bd | PubMed:21601007
  • Castello-Cros, R., Bonuccelli, G., Molchansky, A., Capozza, F., Witkiewicz, A. K., Birbe, R. C., ... Lisanti, M. P. (2011). Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis. Cell Cycle, 10(12), 2021-2034. DOI:10.4161/cc.10.12.16002
    . Publication link: eb4ea950-3768-47c0-b1cf-cd560bffd1b6 | PubMed:21646868
  • Castello-Cros, R., Whitaker-Menezes, D., Molchansky, A., Purkins, G., Soslowsky, L. J., Beason, D. P., ... Lisanti, M. P. (2011). Scleroderma-like properties of skin from caveolin-1-deficient mice: Implications for new treatment strategies in patients with fibrosis and systemic sclerosis. Cell Cycle, 10(13), 2140-2150. DOI:10.4161/cc.10.13.16227
    . Publication link: 2ac3e41b-ba1a-403c-9599-d3fcfd9fcabf | PubMed:21670602
  • Chi, Y., Min, J., Jasmin, J. F., Lisanti, M. P., Chang, Y. T., & Schuster, V. L. (2011). Development of a high-affinity inhibitor of the prostaglandin transporter. Journal of Pharmacology and Experimental Therapeutics, 339(2), 633-641. DOI:10.1124/jpet.111.181354
    . Publication link: ff492da5-656d-4d28-98f2-131b6622b6bb | PubMed:21849625
  • Chiavarina, B., Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Witkiewicz, A. K., Birbe, R. C., Howell, A., ... Lisanti, M. P. (2011). Pyruvate kinase expression (PKM1 and PKM2) in cancer associated fibroblasts drives stromal nutrient production and tumor growth. Cancer Biology and Therapy, 12(12), 1101-1113. DOI:10.4161/cbt.12.12.18703
    . Publication link: 5c056743-58a3-4649-a2fb-c482a60592e1 | PubMed:22236875
  • Crist, R. C., Roth, J. J., Lisanti, M. P., Siracusa, L. D., & Buchberg, A. M. (2011). Identification of Mom12 and Mom13, two novel modifier loci of Apc Min-mediated intestinal tumorigenesis. Cell Cycle, 10(7), 1092-1099. DOI:10.4161/cc.10.7.15089
    . Publication link: ef690b21-5915-49a0-a671-8c52039e25fc | PubMed:21386660
  • De Almeida, C. J., Witkiewicz, A. K., Jasmin, J. F., Tanowitz, H. B., Sotgia, F., Frank, P. G., & Lisanti, M. P. (2011). Caveolin-2-deficient mice show increased sensitivity to endotoxemia. Cell Cycle, 10(13), 2151-2161. DOI:10.4161/cc.10.13.16234
    . Publication link: 4ebb83b9-082f-41a4-9f8e-df96d1f580aa | PubMed:21670588
  • Feiner, E. C., Chung, P., Jasmin, J. F., Zhang, J., Whitaker-Menezes, D., Myers, V., ... Feldman, A. M. (2011). Left ventricular dysfunction in murine models of heart failure and in failing human heart is associated with a selective decrease in the expression of caveolin-3. Journal of Cardiac Failure, 17(3), 253-263. DOI:10.1016/j.cardfail.2010.10.008
    . Publication link: a659d149-df55-415d-a317-a94e1396d6f6 | PubMed:21362533
  • Freeman, M. R., Kim, J., Lisanti, M. P., & Di Vizio, D. (2011). A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death. Cancer Biology and Therapy, 12(11), 966-977. DOI:10.4161/cbt.12.11.18136
    . Publication link: 1511fd3b-e173-4a82-86ae-44736f8bf21c | PubMed:22108021
  • Huang, H., Ma, Y. F., Bao, Y., Lee, H., Lisanti, M. P., Tanowitz, H. B., & Weiss, L. M. (2011). Molecular cloning and characterization of mitogen-activated protein kinase 2 in Toxoplasma gondii. Cell Cycle, 10(20), 3519-3526. DOI:10.4161/cc.10.20.17791
    . Publication link: b985f0a7-dce3-47a3-8a67-07ad858ed020 | PubMed:22030559
  • Janowski, E., Jiao, X., Katiyar, S., Lisanti, M. P., Liu, M., Pestell, R. G., & Morad, M. (2011). c-Jun is required for TGF-β-mediated cellular migration via nuclear Ca2+ signaling. International Journal of Biochemistry and Cell Biology, 43(8), 1104-1113. DOI:10.1016/j.biocel.2011.03.011
    . Publication link: 94cbc53a-539c-4c2d-88be-4c498610ca6c | PubMed:21447400
  • Jasmin, J. F., Rengo, G., Lymperopoulos, A., Gupta, R., Eaton, G. J., Quann, K., ... Lisanti, M. P. (2011). Caveolin-1 deficiency exacerbates cardiac dysfunction and reduces survival in mice with myocardial infarction. American Journal of Physiology - Heart and Circulatory Physiology, 300(4), H1274-H1281. DOI:10.1152/ajpheart.01173.2010
    . Publication link: b94eb52c-c9d0-4c98-82e3-c7a657277db8 | PubMed:21297026
  • Ko, Y. H., Lin, Z., Flomenberg, N., Pestell, R. G., Howell, A., Sotgia, F., ... Martinez-Outschoorn, U. E. (2011). Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: Implications for preventing chemotherapy resistance. Cancer Biology and Therapy, 12(12), 1085-1097. DOI:10.4161/cbt.12.2.18671
    . Publication link: 05171de6-92c7-449f-aea0-4c1b4e517430 | PubMed:22236876
  • Lisanti, M. P., Martinez-Outschoorn, U. E., Lin, Z., Pavlides, S., Whitaker-Menezes, D., Pestell, R. G., ... Sotgia, F. (2011). Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: The seed and soil also needs "fertilizer". Cell Cycle, 10(15), 2440-2449. DOI:10.4161/cc.10.15.16870
    . Publication link: a79c6300-04a0-4c6c-ba64-948a242e577c | PubMed:21734470
  • Lisanti, M. P., Martinez-Outschoorn, U. E., Pavlides, S., Whitaker-Menezes, D., Pestell, R. G., Howell, A., & Sotgia, F. (2011). Accelerated aging in the tumor microenvironment: Connecting aging, inflammation and cancer metabolism with personalized medicine. Cell Cycle, 10(13), 2059-2063. DOI:10.4161/cc.10.13.16233
    . Publication link: 917dac5d-93ad-4951-9738-a910eb72dd14 | PubMed:21654190
  • Llaverias, G., Danilo, C., Mercier, I., Daumer, K., Capozza, F., Williams, T. M., ... Frank, P. G. (2011). Role of cholesterol in the development and progression of breast cancer. American Journal of Pathology, 178(1), 402-412. DOI:10.1016/j.ajpath.2010.11.005
    . Publication link: 0d9e0fb0-9a1a-4bd4-93ad-894428a88677 | PubMed:21224077
  • Martinez-Outschoorn, U. E., Goldberg, A., Lin, Z., Ko, Y. H., Flomenberg, N., Wang, C., ... Lisanti, M. P. (2011). Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells. Cancer Biology and Therapy, 12(10), 924-938. DOI:10.4161/cbt.12.10.17780
    . Publication link: 93761817-2481-4728-b796-16468022f223 | PubMed:22041887
  • Martinez-Outschoorn, U. E., Lin, Z., Ko, Y. H., Goldberg, A. F., Flomenberg, N., Wang, C., ... Lisanti, M. P. (2011). Understanding the metabolic basis of drug resistance: Therapeutic induction of the Warburg effect kills cancer cells. Cell Cycle, 10(15), 2521-2528. DOI:10.4161/cc.10.15.16584
    . Publication link: 20da1c7b-599f-42da-9a82-12895a948b47 | PubMed:21768775
  • Martinez-Outschoorn, U. E., Lin, Z., Trimmer, C., Flomenberg, N., Wang, C., Pavlides, S., ... Lisanti, M. P. (2011). Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: Implications for PET imaging of human tumors. Cell Cycle, 10(15), 2504-2520. DOI:10.4161/cc.10.15.16585
    . Publication link: 6ab49782-d61a-41bf-8a56-54669581b8a2 | PubMed:21778829
  • Martinez-Outschoorn, U. E., Pavlides, S., Howell, A., Pestell, R. G., Tanowitz, H. B., Sotgia, F., & Lisanti, M. P. (2011). Stromal-epithelial metabolic coupling in cancer: Integrating autophagy and metabolism in the tumor microenvironment. International Journal of Biochemistry and Cell Biology, 43(7), 1045-1051. DOI:10.1016/j.biocel.2011.01.023
    . Publication link: d64449a9-8b61-4802-a479-20c965c845bc | PubMed:21300172
  • Martinez-Outschoorn, U. E., Pavlides, S., Sotgia, F., & Lisanti, M. P. (2011). Mitochondrial biogenesis drives tumor cell proliferation. American Journal of Pathology, 178(5), 1949-1952. DOI:10.1016/j.ajpath.2011.03.002
    . Publication link: 5834f5de-59f9-42c6-bc5e-3b8ea8336b96 | PubMed:21514412
  • Martinez-Outschoorn, U. E., Pestell, R. G., Howell, A., Tykocinski, M. L., Nagajyothi, F., Machado, F. S., ... Lisanti, M. P. (2011). Energy transfer in "parasitic" cancer metabolism: Mitochondria are the powerhouse and Achilles' heel of tumor cells. Cell Cycle, 10(24), 4208-4216. DOI:10.4161/cc.10.24.18487
    . Publication link: 7e37d454-8374-4082-b791-ea4542f45949 | PubMed:22033146
  • Martinez-Outschoorn, U. E., Prisco, M., Ertel, A., Tsirigos, A., Lin, Z., Pavlides, S., ... Lisanti, M. P. (2011). Ketones and lactate increase cancer cell "stemness", driving recurrence, metastasis and poor clinical outcome in breast cancer: Achieving personalized medicine via metabolo-genomics. Cell Cycle, 10(8), 1271-1286. DOI:10.4161/cc.10.8.15330
    . Publication link: aab1a68c-de81-483c-bac1-0f2f703c54c7 | PubMed:21490415
  • Martinez-Outschoorn, U. E., Whitaker-Menezes, D., Lin, Z., Flomenberg, N., Howell, A., Pestell, R. G., ... Sotgia, F. (2011). Cytokine production and inflammation drive autophagy in the tumor microenvironment: Role of stromal caveolin-1 as a key regulator. Cell Cycle, 10(11), 1784-1793. DOI:10.4161/cc.10.11.15674
    . Publication link: 84edce1f-06c1-4638-8943-79b161908d44 | PubMed:21566463
  • Meng, H., Tian, L., Zhou, J., Li, Z., Jiao, X., Li, W. W., ... Pestell, R. G. (2011). PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b. Cell Cycle, 10(1), 73-81. DOI:10.4161/cc.10.1.14243
    . Publication link: 06791753-f5a2-4b40-b020-2113b11cbbe7 | PubMed:21200149
  • Ren, G., Jacob, R. F., Kaulin, Y., DiMuzio, P., Xie, Y., Mason, R. P., ... Tulenko, T. N. (2011). Alterations in membrane caveolae and BK Ca channel activity in skin fibroblasts in Smith-Lemli-Opitz syndrome. Molecular Genetics and Metabolism, 104(3), 346-355. DOI:10.1016/j.ymgme.2011.04.019
    . Publication link: 27299860-7ed0-4ef1-b54c-59ee9a818e03 | PubMed:21724437
  • Salem, A. F., Bonuccelli, G., Bevilacqua, G., Arafat, H., Pestell, R. G., Sotgia, F., & Lisanti, M. P. (2011). Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition. Cell Cycle, 10(21), 3692-3700. DOI:10.4161/cc.10.21.17895
    . Publication link: f825083e-87bc-4f59-a837-1058fac775bf | PubMed:22041584
  • Soares, M. B. P., Lima, R. S., Souza, B. S. F., Vasconcelos, J. F., Rocha, L. L., Dos Santos, R. R., ... De Campos Carvalho, A. C. (2011). Reversion of gene expression alterations in hearts of mice with chronic chagasic cardiomyopathy after transplantation of bone marrow cells. Cell Cycle, 10(9), 1448-1455. DOI:10.4161/cc.10.9.15487
    . Publication link: ef6a66e6-e697-4d69-90a6-ea927911c74d | PubMed:21467843
  • Sotgia, F., Martinez-Outschoorn, U. E., & Lisanti, M. P. (2011). Mitochondrial oxidative stress drives tumor progression and metastasis: Should we use antioxidants as a key component of cancer treatment and prevention?. BMC Medicine, 9, [62]. DOI:10.1186/1741-7015-9-62
    . Publication link: 6fe5de79-8c44-45d1-9647-7a61a997a176 | PubMed:21605374
  • Sotgia, F., Martinez-Outschoorn, U. E., Pavlides, S., Howell, A., Pestell, R. G., & Lisanti, M. P. (2011). Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment.Breast Cancer Research, 13(4), 213. DOI:10.1186/bcr2892
    . Publication link: fcf67ae6-dc66-4f5c-b80d-f983ba5515cb | PubMed:21867571
  • Tanowitz, H. B., Mukhopadhyay, A., Ashton, A. W., Lisanti, M. P., Machado, F. S., Weiss, L. M., & Mukherjee, S. (2011). Microarray analysis of the mammalian thromboxane receptor-Trypanosoma cruzi interaction. Cell Cycle, 10(7), 1132-1143. DOI:10.4161/cc.10.7.15207
    . Publication link: 319dca52-5eed-479c-82a0-b2cd36606e10 | PubMed:21364319
  • Thomas, N. M., Jasmin, J. F., Lisanti, M. P., & Iacobas, D. A. (2011). Sex differences in expression and subcellular localization of heart rhythm determinant proteins. Biochemical and Biophysical Research Communications, 406(1), 117-122. DOI:10.1016/j.bbrc.2011.02.006
    . Publication link: a5c0ef4f-2080-4343-9b14-ad6a9332744a | PubMed:21296051
  • Trimmer, C., Sotgia, F., Whitaker-Menezes, D., Balliet, R. M., Eaton, G., Martinez-Outschoorn, U. E., ... Lisanti, M. P. (2011). Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: A new genetically tractable model for human cancer associated fibroblasts. Cancer Biology and Therapy, 11(4), 383-394. DOI:10.4161/cbt.11.4.14101
    . Publication link: 9ac7f6ac-98db-4002-99b0-a86b22e3dad2 | PubMed:21150282
  • Velasco-Velázquez, M. A., Popov, V. M., Lisanti, M. P., & Pestell, R. G. (2011). The role of breast cancer stem cells in metastasis and therapeutic implications. American Journal of Pathology, 179(1), 2-11. DOI:10.1016/j.ajpath.2011.03.005
    . Publication link: b3ecd0e5-2aea-4bde-9873-62cb99b6bbf3 | PubMed:21640330
  • Wang, C., Lisanti, M. P., & Liao, D. J. (2011). Reviewing once more the c-myc and Ras collaboration: Converging at the cyclin D1-CDK4 complex and challenging basic concepts of cancer biology. Cell Cycle, 10(1), 57-67. DOI:10.4161/cc.10.1.14449
    . Publication link: 80dcaeff-9e23-481e-827b-75e9f74f0454 | PubMed:21200143
  • Wang, C., Tai, Y., Lisanti, M. P., & Liao, D. J. (2011). c-Myc induction of programmed cell death may contribute to carcinogenesis: A perspective inspired by several concepts of chemical carcinogenesis. Cancer Biology and Therapy, 11(7), 615-626. DOI:10.4161/cbt.11.7.14688
    . Publication link: f70c8f21-70d0-4cca-aa96-e585033c6bb3 | PubMed:21278493
  • Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Flomenberg, N., Birbe, R. C., Witkiewicz, A. K., Howell, A., ... Sotgia, F. (2011). Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue. Cell Cycle, 10(23), 4047-4064. DOI:10.4161/cc.10.23.18151
    . Publication link: 8e4929c6-c7e3-436d-92c3-db73eccb561b | PubMed:22134189
  • Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Lin, Z., Ertel, A., Flomenberg, N., Witkiewicz, A. K., ... Lisanti, M. P. (2011). Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts. Cell Cycle, 10(11), 1772-1783. DOI:10.4161/cc.10.11.15659
    . Publication link: 1a7d8a7d-2ce5-47e4-aecd-8bf8ffd739ec | PubMed:21558814
  • Witkiewicz, A. K., Kline, J., Queenan, M., Brody, J. R., Tsirigos, A., Bilal, E., ... Lisanti, M. P. (2011). Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers. Cell Cycle, 10(11), 1794-1809. DOI:10.4161/cc.10.11.15675
    . Publication link: f89ff30e-526d-4992-9746-30db695df7f2 | PubMed:21521946
  • Wu, K. N., Queenan, M., Brody, J. R., Potoczek, M., Sotgia, F., Lisanti, M. P., & Witkiewicz, A. K. (2011). Loss of stromal Caveolin-1 expression in malignant melanoma metastases predicts poor survival. Cell Cycle, 10(24), 4250-4255. DOI:10.4161/cc.10.24.18551
    . Publication link: 18bbc78c-a85d-428c-8cd5-83e2537f1a28 | PubMed:22134245

2010

  • Adesse, D., Lisanti, M. P., Spray, D. C., Machado, F. S., Meirelles, M. D. N., Tanowitz, H. B., & Garzoni, L. R. (2010). Trypanosoma cruzi infection results in the reduced expression of caveolin-3 in the heart. Cell Cycle, 9(8), 1639-1646.
    . Publication link: 60ec31a2-98f1-428f-8803-b06dbb37da85 | PubMed:20372051
  • Bao, Y., Weiss, L. M., Ma, Y. F., Lisanti, M. P., Tanowitz, H. B., Das, B. C., ... Huang, H. (2010). Molecular cloning and characterization of mitogen-activated protein kinase 2 in Trypanosoma cruzi. Cell Cycle, 9(14), 2888-2896. DOI:10.4161/cc.9.14.12372
    . Publication link: ce055d24-a1fe-4450-8be5-651fff90973b | PubMed:20603604
  • Bonuccelli, G., Tsirigos, A., Whitaker-Menezes, D., Pavlides, S., Pestell, R. G., Chiavarina, B., ... Lisanti, M. P. (2010). Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle, 9(17), 3506-3514. DOI:10.4161/cc.9.17.12731
    . Publication link: 3d974ca5-d13f-4f5a-92a2-3ced8fcbb429 | PubMed:20818174
  • Bonuccelli, G., Whitaker-Menezes, D., Castello-Cros, R., Pavlides, S., Pestell, R. G., Fatatis, A., ... Lisanti, M. P. (2010). The reverse Warburg effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts. Cell Cycle, 9(10), 1960-1971. DOI:10.4161/cc.9.10.11601
    . Publication link: e8d610ed-8a0b-4cbb-957c-6bd72a3009e7 | PubMed:20495363
  • Chiavarina, B., Whitaker-Menezes, D., Migneco, G., Martinez-Outschoorn, U. E., Pavlides, S., Howell, A., ... Lisanti, M. P. (2010). HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis. Cell Cycle, 9(17), 3534-3551. DOI:10.4161/cc.9.17.12908
    . Publication link: 0df0605f-7538-456f-a6c7-2168d4f615a9 | PubMed:20864819
  • Gazzerro, E., Assereto, S., Bonetto, A., Sotgia, F., Scarfi, S., Pistorio, A., ... Minetti, C. (2010). Therapeutic potential of proteasome inhibition in Duchenne and Becker muscular dystrophies. American Journal of Pathology, 176(4), 1863-1877. DOI:10.2353/ajpath.2010.090468
    . Publication link: 82014b29-3867-47e5-8349-86bd6486e8d7 | PubMed:20304949
  • Gazzerro, E., Sotgia, F., Bruno, C., Lisanti, M. P., & Minetti, C. (2010). Caveolinopathies: From the biology of caveolin-3 to human diseases. European Journal of Human Genetics, 18(2), 137-145. DOI:10.1038/ejhg.2009.103
    . Publication link: 4a869911-95bc-4959-82fc-570f556f9c3b | PubMed:19584897
  • Gu, L., Dagvadorj, A., Lutz, J., Leiby, B., Bonuccelli, G., Lisanti, M. P., ... Nevalainen, M. T. (2010). Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth. American Journal of Pathology, 176(4), 1959-1972. DOI:10.2353/ajpath.2010.090653
    . Publication link: dba2ef88-3aca-4a08-89d2-8dd2c78c0f27 | PubMed:20167868
  • Jiao, X., Katiyar, S., Willmarth, N. E., Liu, M., Ma, X., Flomenberg, N., ... Pestell, R. G. (2010). c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion. Journal of Biological Chemistry, 285(11), 8218-8226. DOI:10.1074/jbc.M110.100792
    . Publication link: 01863369-6add-4e17-bfd5-e1e7dffb338d | PubMed:20053993
  • Lisanti, M. P., Martinez-Outschoorn, U. E., Chiavarina, B., Pavlides, S., Whitaker-Menezes, D., Tsirigos, A., ... Sotgia, F. (2010). Understanding the "lethal" drivers of tumor-stroma co-evolution: Emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment. Cancer Biology and Therapy, 10(6), 537-542. DOI:10.4161/cbt.10.6.13370
    . Publication link: c7fdcdf2-125e-4319-beb5-98a67e4b29e0 | PubMed:20861671
  • Liu, M., Sakamaki, T., Casimiro, M. C., Willmarth, N. E., Quong, A. A., Ju, X., ... Pestell, R. G. (2010). The canonical NF-κB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion. Cancer Research, 70(24), 10464-10473. DOI:10.1158/0008-5472.CAN-10-0732
    . Publication link: 6e6d81b1-4f27-42c5-b1d2-4d0eef86958c | PubMed:21159656
  • Llaverias, G., Danilo, C., Wang, Y., Witkiewicz, A. K., Daumer, K., Lisanti, M. P., & Frank, P. G. (2010). A western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer. American Journal of Pathology, 177(6), 3180-3191. DOI:10.2353/ajpath.2010.100568
    . Publication link: e1e01635-bacb-437e-9002-c3e4b0ae34e8 | PubMed:21088217
  • Martinez-Outschoorn, U. E., Balliet, R. M., Rivadeneira, D. B., Chiavarina, B., Pavlides, S., Wang, C., ... Lisanti, M. P. (2010). Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle, 9(16), 3256-3276. DOI:10.4161/cc.9.16.12553
    . Publication link: ddf99477-8974-4d3b-8f4b-170a6007b755 | PubMed:20814239
  • Martinez-Outschoorn, U. E., Pavlides, S., Whitaker-Menezes, D., Daumer, K. M., Milliman, J. N., Chiavarina, B., ... Sotgia, F. (2010). Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors. Cell Cycle, 9(12), 2423-2433. DOI:10.4161/cc.9.12.12048
    . Publication link: b4e6c52f-f9d0-4b8b-ab35-6ca872ecb80d | PubMed:20562526
  • Martinez-Outschoorn, U. E., Trimmer, C., Lin, Z., Whitaker-Menezes, D., Chiavarina, B., Zhou, J., ... Sotgia, F. (2010). Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle, 9(17), 3515-3533. DOI:10.4161/cc.9.17.12928
    . Publication link: 674e7332-b735-42da-9bb5-8062271371fd | PubMed:20855962
  • Martinez-Outschoorn, U. E., Whitaker-Menezes, D., Pavlides, S., Chiavarina, B., Bonuccelli, G., Trimmer, C., ... Lisanti, M. P. (2010). The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox. Cell Cycle, 9(21), 4297-4306. DOI:10.4161/cc.9.21.13817
    . Publication link: 54f5ff64-cb04-46b1-bc72-a2a3a5815f19 | PubMed:21051947
  • Migneco, G., Whitaker-Menezes, D., Chiavarina, B., Castello-Cros, R., Pavlides, S., Pestell, R. G., ... Lisanti, M. P. (2010). Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: Evidence for stromal-epithelial metabolic coupling. Cell Cycle, 9(12), 2412-2422. DOI:10.4161/cc.9.12.11989
    . Publication link: 14bd46a8-17a6-47c7-987a-408ad2d1cd71 | PubMed:20562527
  • Park, H. C., Yasuda, K., Ratliff, B., Stoessel, A., Sharkovska, Y., Yamamoto, I., ... Goligorsky, M. S. (2010). Postobstructive regeneration of kidney is derailed when surge in renal stem cells during course of unilateral ureteral obstruction is halted. American Journal of Physiology - Renal Physiology, 298(2), F357-F364. DOI:10.1152/ajprenal.00542.2009
    . Publication link: 1c38e297-10c2-4369-a932-9dd3796c22ac | PubMed:19906947
  • Pavlides, S., Tsirigos, A., Migneco, G., Whitaker-Menezes, D., Chiavarina, B., Flomenberg, N., ... Lisanti, M. P. (2010). The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism. Cell Cycle, 9(17), 3485-3505. DOI:10.4161/cc.9.17.12721
    . Publication link: c333537d-d2a5-42d7-a732-461025184c8b | PubMed:20861672
  • Pavlides, S., Tsirigos, A., Vera, I., Flomenberg, N., Frank, P. G., Casimiro, M. C., ... Lisanti, M. P. (2010). Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": A transcriptional informatics analysis with validation. Cell Cycle, 9(11), 2201-2219. DOI:10.4161/cc.9.11.11848
    . Publication link: 55dae96d-e42c-41c6-b450-5ea22815366c | PubMed:20519932
  • Pavlides, S., Tsirigos, A., Vera, I., Flomenberg, N., Frank, P. G., Casimiro, M. C., ... Lisanti, M. P. (2010). Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling".Aging, 2(4).
    . Publication link: c9030b17-bbe9-4479-8433-5b989ec549a2 | PubMed:20442453
  • Ratliff, B. B., Singh, N., Yasuda, K., Park, H. C., Addabbo, F., Ghaly, T., ... Goligorsky, M. S. (2010). Mesenchymal stem cells, used as bait, disclose tissue binding sites: A tool in the search for the niche?. American Journal of Pathology, 177(2), 873-883. DOI:10.2353/ajpath.2010.090984
    . Publication link: f9b00d3f-8f53-449d-b725-cd03eb48a56d | PubMed:20558574
  • Rengo, G., Leosco, D., Zincarelli, C., Marchese, M., Corbi, G., Liccardo, D., ... Lymperopoulos, A. (2010). Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure. American Journal of Physiology - Heart and Circulatory Physiology, 298(6), H2032-H2038. DOI:10.1152/ajpheart.00702.2009
    . Publication link: c9981cf1-0251-4fde-a2f7-ebc66215add0 | PubMed:20304818
  • Ringer, L., Sirajuddin, P., Yenugonda, V. M., Ghosh, A., Divito, K., Trabosh, V., ... Albanese, C. (2010). VMY-1-103, a dansylated analog of purvalanol B, induces caspase-3-dependent apoptosis in LNCaP prostate cancer cells. Cancer Biology and Therapy, 10(4), 320-325. DOI:10.4161/cbt.10.4.12208
    . Publication link: c315c97b-263a-49fb-8dbf-0a4e5d96ce6f | PubMed:20574155
  • Smith, J. A., Ndoye, A. M. N., Geary, K., Lisanti, M. P., Igoucheva, O., & Daniel, R. (2010). A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4. Aging Cell, 9(4), 580-591. DOI:10.1111/j.1474-9726.2010.00585.x
    . Publication link: 320a8f36-55e0-4852-b445-a68e351dc8c0 | PubMed:20477760
  • Trimmer, C., Whitaker-Menezes, D., Bonuccelli, G., Milliman, J. N., Daumer, K. M., Aplin, A. E., ... Capozza, F. (2010). CAV1 inhibits metastatic potential in melanomas through suppression of the integrin/Src/FAK signaling pathway. Cancer Research, 70(19), 7489-7499. DOI:10.1158/0008-5472.CAN-10-0900
    . Publication link: dc64750d-2eb9-4898-8741-8960f8272c0c | PubMed:20709760
  • Vissapragada, S., Ghosh, A., Ringer, L., Salinas, P., Brophy, A., Peaceman, D., ... Albanese, C. (2010). Dietary n-3 polyunsaturated fatty acids fail to reduce prostate tumorigenesis in the PB-ErbB-2 x Pten+/- preclinical mouse model. Cell Cycle, 9(9), 1824-1829. DOI:10.4161/cc.9.9.11542
    . Publication link: a0c141b5-13b7-4447-bb05-1f1982457334 | PubMed:20404514
  • Witkiewicz, A. K., Dasgupta, A., Sammons, S., Er, O., Potoczek, M. B., Guiles, F., ... Lisanti, M. P. (2010). Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers. Cancer Biology and Therapy, 10(2), 135-143.
    . Publication link: 62641ff1-6705-4f7a-ab34-dad9a1ddc529 | PubMed:20431349
  • Witkiewicz, A. K., Freydin, B., Chervoneva, I., Potoczek, M., Rizzo, W., Rui, H., ... Lisanti, M. P. (2010). Stromal CD10 and SPARC expression in ductal carcinoma in situ (DCIS) patients predicts disease recurrence. Cancer Biology and Therapy, 10(4), 391-396. DOI:10.4161/cbt.10.4.12449
    . Publication link: b770405f-4bed-40a0-9c71-70437ea7921b | PubMed:20574156
  • Xie, L., Frank, P. G., Lisanti, M. P., & Sowa, G. (2010). Endothelial cells isolated from caveolin-2 knockout mice display higher proliferation rate and cell cycle progression relative to their wild-type counterparts. American Journal of Physiology - Cell Physiology, 298(3), C693-C701. DOI:10.1152/ajpcell.00401.2009
    . Publication link: 7fb57c14-1845-42be-8502-ca3145b9a970 | PubMed:20007452
  • Yu, Z., Baserga, R., Chen, L., Wang, C., Lisanti, M. P., & Pestell, R. G. (2010). MicroRNA, cell cycle, and human breast cancer. American Journal of Pathology, 176(3), 1058-1064. DOI:10.2353/ajpath.2010.090664
    . Publication link: 64d15099-6ce6-4733-8dec-9e4239ebe718 | PubMed:20075198
  • Yu, Z., Willmarth, N. E., Zhou, J., Katiyar, S., Wang, M., Liu, Y., ... Pestell, R. G. (2010). microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proceedings of the National Academy of Sciences of the United States of America, 107(18), 8231-8236. DOI:10.1073/pnas.1002080107
    . Publication link: 7c9e62b9-9569-426f-a921-a338ffbecf86 | PubMed:20406904
  • Zhou, J., Wang, C., Wang, Z., Dampier, W., Wu, K., Casimiro, M. C., ... Pestell, R. G. (2010). Attenuation of Forkhead signaling by the retinal determination factor DACH1. Proceedings of the National Academy of Sciences of the United States of America, 107(15), 6864-6869. DOI:10.1073/pnas.1002746107
    . Publication link: b98d11b4-6ccf-42d5-a419-16f6003d20f8 | PubMed:20351289
  • Zhu, H., Suk, H. Y., Yu, R. Y. L., Brancho, D., Olabisi, O., Yang, T. T. C., ... Chow, C. W. (2010). Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D. Molecular and Cellular Biology, 30(18), 4379-4390. DOI:10.1128/MCB.01193-09
    . Publication link: 312b477c-bb8c-491f-b7a8-87f57f87a1c8 | PubMed:20647544

2009

  • Bonuccelli, G., Casimiro, M. C., Sotgia, F., Wang, C., Liu, M., Katiyar, S., ... Lisanti, M. P. (2009). Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature. American Journal of Pathology, 174(5), 1650-1662. DOI:10.2353/ajpath.2009.080648
    . Publication link: 0a137aad-2270-4987-88aa-27ffbefc56dd | PubMed:19395651
  • Brody, J. R., Costantino, C. L., Berger, A. C., Sato, T., Lisanti, M. P., Yeo, C. J., ... Witkiewicz, A. K. (2009). Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival. Cell Cycle, 8(12), 1930-1934.
    . Publication link: 6694075f-001a-4221-adce-3a99a2d503e3 | PubMed:19448397
  • Di Vizio, D., Morello, M., Sotgia, F., Pestell, R. G., Freeman, M. R., & Lisanti, M. P. (2009). An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation. Cell Cycle, 8(15), 2420-2424.
    . Publication link: a3192db4-5ea0-440d-9e77-bdf64a79a2fe | PubMed:19556867
  • Di Vizio, D., Morello, M., Sotgia, F., Pestell, R. G., Freeman, M. R., & Lisanti, M. P. (2009). An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease spread and epithelial Akt activation. Cell Cycle, 8(15), 2420. DOI:10.4161/cc.8.15.9116
    . Publication link: 0604b229-9fa1-4f2b-9102-e60b29c7e00d | PubMed:19556867
  • Felicetti, F., Parolini, I., Bottero, L., Fecchi, K., Errico, M. C., Raggi, C., ... Carè, A. (2009). Caveolin-1 tumor-promoting role in human melanoma. International Journal of Cancer, 125(7), 1514-1522. DOI:10.1002/ijc.24451
    . Publication link: 8ef8aaf2-4277-4ab7-8eb2-e1489af2278d | PubMed:19521982
  • Frank, P. G., Pavlides, S., & Lisanti, M. P. (2009). Caveolae and transcytosis in endothelial cells: Role in atherosclerosis. Cell and Tissue Research, 335(1), 41-47. DOI:10.1007/s00441-008-0659-8
    . Publication link: 65c3be78-739d-4419-bc3d-f82c340a9b93 | PubMed:18688651
  • Jasmin, J. F., Yang, M., Iacovitti, L., & Lisanti, M. P. (2009). Genetic ablation of caveolin-1 increases neural stem cell proliferation in the subventricular zone (SVZ) of the adult mouse brain. Cell Cycle, 8(23), 3978-3983.
    . Publication link: 77e46f77-de6f-4dbf-bc5b-f42fd5392133 | PubMed:19923909
  • Marmon, S., Hinchey, J., Oh, P., Cammer, M., De Almeida, C. J., Gunther, L., ... Lisanti, M. P. (2009). Caveolin-1 expression determines the route of neutrophil extravasation through skin microvasculature. American Journal of Pathology, 174(2), 684-692. DOI:10.2353/ajpath.2009.080091
    . Publication link: 99e563be-df4e-4d86-8686-9593557adc96 | PubMed:19164603
  • Mercier, I., Bryant, K. G., Sotgia, F., Bonuccelli, G., Witkiewicz, A. K., Dasgupta, A., ... Lisanti, M. P. (2009). Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation. Cell Cycle, 8(9), 1396-1401.
    . Publication link: 1b9a7ebe-28db-4990-9bab-2f12854f9754 | PubMed:19342880
  • Mercier, I., Casimiro, M. C., Zhou, J., Wang, C., Plymire, C., Bryant, K. G., ... Lisanti, M. P. (2009). Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions. American Journal of Pathology, 174(4), 1172-1190. DOI:10.2353/ajpath.2009.080882
    . Publication link: dc009fcf-0b69-4d23-9846-79845e2417e3 | PubMed:19342371
  • Mercier, I., Jasmin, J. F., Pavlides, S., Minetti, C., Flomenberg, N., Pestell, R. G., ... Lisanti, M. P. (2009). Clinical and translational implications of the caveolin gene family: Lessons from mouse models and human genetic disorders. Laboratory Investigation, 89(6), 614-623. DOI:10.1038/labinvest.2009.23
    . Publication link: 269bd39e-9fdb-4e9f-ac41-b660f0d661db | PubMed:19333235
  • Nagajyothi, F., Desruisseaux, M. S., Weiss, L. M., Chua, S., Albanese, C., Machado, F. S., ... Tanowitz, H. B. (2009). Chagas disease, adipose tissue and the metabolic syndrome. Memorias do Instituto Oswaldo Cruz, 104(1), 219-225.
    . Publication link: ea045e07-ca3d-4baa-835a-0ad04c36ee63 | PubMed:19753477
  • Nan, F., Lü, Q., Zhou, J., Cheng, L., Popov, V. M., Wei, S., ... Wang, C. (2009). Altered expression of DACH1 and cyclin D1 in endometrial cancer. Cancer Biology and Therapy, 8(16).
    . Publication link: e12b63e1-59cf-42ac-958e-fcce38c1b619 | PubMed:19502783
  • Pavlides, S., Whitaker-Menezes, D., Castello-Cros, R., Flomenberg, N., Witkiewicz, A. K., Frank, P. G., ... Lisanti, M. P. (2009). The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle, 8(23), 3984-4001. DOI:10.4161/cc.8.23.10238
    . Publication link: fa5e7bdc-19b5-4957-a88a-33706cfb22dc | PubMed:19923890
  • Rodriguez, O. C., Lai, E. W., Vissapragada, S., Cromelin, C., Avetian, M., Salinas, P., ... Albanese, C. (2009). A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1. American Journal of Pathology, 174(6), 2051-2060. DOI:10.2353/ajpath.2009.080859
    . Publication link: fcdbf6ee-d33b-4778-8052-5682e537d997 | PubMed:19443706
  • Sotgia, F., Casimiro, M. C., Bonuccelli, G., Liu, M., Whitaker-Menezes, D., Er, O., ... Lisanti, M. P. (2009). Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation. American Journal of Pathology, 174(2), 613-629. DOI:10.2353/ajpath.2009.080653
    . Publication link: 434b8562-7c83-41f1-8e22-25bac47c3764 | PubMed:19164602
  • Sotgia, F., Del Galdo, F., Casimiro, M. C., Bonuccelli, G., Mercier, I., Whitaker-Menezes, D., ... Lisanti, M. P. (2009). Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. American Journal of Pathology, 174(3), 746-761. DOI:10.2353/ajpath.2009.080658
    . Publication link: f35dbb43-1a1d-46ed-ab59-715c7f72cea3 | PubMed:19234134
  • Witkiewicz, A. K., Casimiro, M. C., Dasgupta, A., Mercier, I., Wang, C., Bonuccelli, G., ... Lisanti, M. P. (2009). Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy. Cell Cycle, 8(11), 1654-1658.
    . Publication link: 0bf5674e-d5de-49d5-a601-72a19408d65d | PubMed:19448435
  • Witkiewicz, A. K., Dasgupta, A., Nguyen, K. H., Liu, C., Kovatich, A. J., Schwartz, G. F., ... Lisanti, M. P. (2009). Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer. Cancer Biology and Therapy, 8(11), 1071-1079. DOI:10.4161/cbt.8.11.8874
    . Publication link: f8eda31e-f2d3-4ccf-9d9c-0d68ebf56660 | PubMed:19502809
  • Witkiewicz, A. K., Dasgupta, A., Sotgia, F., Mercier, I., Pestell, R. G., Sabel, M., ... Lisanti, M. P. (2009). An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers. American Journal of Pathology, 174(6), 2023-2034. DOI:10.2353/ajpath.2009.080873
    . Publication link: 9b991dec-6616-4a7e-ae56-9c1079413b45 | PubMed:19411448
  • Wu, K. N., Emmons, R. V. B., Lisanti, M. P., Farber, J. L., & Witkiewicz, A. K. (2009). Foxp3-expressing T regulatory cells and mast cells in acute graft-versus-host disease of the skin.Cell cycle (Georgetown, Tex.), 8(21).
    . Publication link: e2ca8518-b90f-4773-a03b-c0b9dc2da57d | PubMed:19838066
  • Zhou, J., Zhang, W., Liang, B., Casimiro, M. C., Whitaker-Menezes, D., Wang, M., ... Wang, C. (2009). PPARγ activation induces autophagy in breast cancer cells. International Journal of Biochemistry and Cell Biology, 41(11), 2334-2342. DOI:10.1016/j.biocel.2009.06.007
    . Publication link: 7cca2ed2-f86c-4f5a-bd5f-b039965ca0ec | PubMed:19563910

2008

  • Abdulghani, J., Gu, L., Dagvadorj, A., Lutz, J., Leiby, B., Bonuccelli, G., ... Nevalainen, M. T. (2008). Stat3 promotes metastatic progression of prostate cancer. American Journal of Pathology, 172(6), 1717-1728. DOI:10.2353/ajpath.2008.071054
    . Publication link: 309bab64-1611-432f-a92c-da420efd48c1 | PubMed:18483213
  • Assereto, S., Mastrototaro, M., Stringara, S., Gazzerro, E., Broda, P., Nicchia, G. P., ... Minetti, C. (2008). Aquaporin-4 expression is severely reduced in human sarcoglycanopathies and dysferlinopathies. Cell Cycle, 7(14), 2199-2207.
    . Publication link: c8c0a9b5-c96d-43d5-bd43-9a0c0c892981 | PubMed:18641458
  • Augustus, A. S., Buchanan, J., Addya, S., Rengo, G., Pestell, R. G., Fortina, P., ... Lisanti, M. P. (2008). Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. American Journal of Physiology - Heart and Circulatory Physiology, 295(2), H657-H666. DOI:10.1152/ajpheart.00387.2008
    . Publication link: dec09b70-face-4d02-860e-a7d3f47a6852 | PubMed:18552160
  • Augustus, A. S., Buchanan, J., Gutman, E., Rengo, G., Pestell, R. G., Fortina, P., ... Lisanti, M. P. (2008). Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism. Cell Cycle, 7(16), 2509-2518.
    . Publication link: 7cc51550-a496-41fa-ace4-ebc3efaed913 | PubMed:18719368
  • Bianco, C., Strizzi, L., Mancino, M., Watanabe, K., Gonzales, M., Hamada, S., ... Salomon, D. S. (2008). Regulation of Cripto-1 signaling and biological activity by caveolin-1 in mammary epithelial cells. American Journal of Pathology, 172(2), 345-357. DOI:10.2353/ajpath.2008.070696
    . Publication link: bfe41db6-e858-4435-82bc-baea7b778ffd | PubMed:18202186
  • Bouzahzah, B., Yurchenko, V., Nagajyothi, F., Hulit, J., Sadofsky, M., Braunstein, V. L., ... Albanese, C. (2008). Regulation of host cell cyclin D1 by Trypanosoma cruzi in myoblasts. Cell Cycle, 7(4), 500-503.
    . Publication link: 54b7531c-af21-4c09-879b-35f7cc694023 | PubMed:18239452
  • Del Galdo, F., Lisanti, M. P., & Jimenez, S. A. (2008). Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosis.Current opinion in rheumatology, 20(6).
    . Publication link: 17fc888c-04a8-4f8d-9dcf-5373deffc3dc | PubMed:18949888
  • Del Galdo, F., Sotgia, F., De Almeida, C. J., Jasmin, J. F., Musick, M., Lisanti, M. P., & Jiménez, S. A. (2008). Decreased expression of caveolin 1 in patients with systemic sclerosis: Crucial role in the pathogenesis of tissue fibrosis. Arthritis and Rheumatism, 58(9), 2854-2865. DOI:10.1002/art.23791
    . Publication link: c4522eea-127e-4a0b-8f2c-86c79b57332d | PubMed:18759267
  • Di Vizio, D., Adam, R. M., Kim, J., Kim, R., Sotgia, F., Williams, T., ... Freeman, M. R. (2008). Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase. Cell Cycle, 7(14), 2257-2267. DOI:10.4161/cc.7.14.6475
    . Publication link: 979b21b3-b6d2-436b-a885-370d3c8cbade | PubMed:18635971
  • Frank, P. G., Pavlides, S., Cheung, M. W. C., Daumer, K., & Lisanti, M. P. (2008). Role of caveolin-1 in the regulation of lipoprotein metabolism. American Journal of Physiology - Cell Physiology, 295(1), C242-C248. DOI:10.1152/ajpcell.00185.2008
    . Publication link: 7682aea0-cad2-4ba5-9b1f-beb66cd13622 | PubMed:18508910
  • Gioiosa, L., Raggi, C., Ricceri, L., Jasmin, J. F., Frank, P. G., Capozza, F., ... Laviola, G. (2008). Altered emotionality, spatial memory and cholinergic function in caveolin-1 knock-out mice. Behavioural Brain Research, 188(2), 255-262. DOI:10.1016/j.bbr.2007.11.002
    . Publication link: 43cf2acf-3db9-493a-a3f5-c9805359b98e | PubMed:18083242
  • Jiao, X., Katiyar, S., Liu, M., Mueller, S. C., Lisanti, M. P., Li, A., ... Pestell, R. G. (2008). Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase. Molecular Biology of the Cell, 19(4), 1378-1390. DOI:10.1091/mbc.E07-08-0753
    . Publication link: bd2bd0b9-d506-4216-8d00-7277d51e4871 | PubMed:18216279
  • Kim, M., Wu, X., Song, I., Fu, M., Chang, S. H., Lisanti, M. P., & Pestell, R. (2008). Selective cytotoxicity of synthesized procyanidin 3-O-galloylepicatechin- 4b, 8-3-O-galloylcatechin to human cancer cells. Cell Cycle, 7(11), 1648-1657.
    . Publication link: 8f7685a1-90ad-4438-a771-b38aef23c5c4 | PubMed:18560275
  • Lindsay, J., Jiao, X., Sakamaki, T., Casimiro, M. C., Shirley, L. A., Tran, T. H., ... Pestell, R. G. (2008). ErbB2 induces Notch1 activity and function in breast cancer cells. Clinical and Translational Science, 1(2), 107-115. DOI:10.1111/j.1752-8062.2008.00041.x
    . Publication link: e8bd4a63-dc42-4ef1-a755-b91574f6069e | PubMed:20443831
  • Mercier, I., Casimiro, M. C., Wang, C., Rosenberg, A. L., Quong, J., Minkeu, A., ... Lisanti, M. P. (2008). Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy. Cancer Biology and Therapy, 7(8), 1212-1225. DOI:10.4161/cbt.7.8.6220
    . Publication link: 3da44c4c-957b-435c-8cd0-2325d3b69ee1 | PubMed:18458534
  • Mercier, I., Vuolo, M., Jasmin, J. F., Medina, C. M., Williams, M., Mariadason, J. M., ... Kitsis, R. N. (2008). ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer. Cell Cycle, 7(11), 1640-1647.
    . Publication link: 8e109bac-ca4f-42b9-b965-d6d3aec88e64 | PubMed:18469522
  • Mukherjee, S., Nagajyothi, F., Mukhopadhyay, A., Machado, F. S., Belbin, T. J., Campos de Carvalho, A., ... Tanowitz, H. B. (2008). Alterations in myocardial gene expression associated with experimental Trypanosoma cruzi infection. Genomics, 91(5), 423-432. DOI:10.1016/j.ygeno.2008.01.008
    . Publication link: 4dd64644-e15d-4e71-ae94-7d1384cda5eb | PubMed:18343633
  • Nagajyothi, F., Desruisseaux, M. S., Thiruvur, N., Weiss, L. M., Braunstein, V. L., Albanese, C., ... Tanowitz, H. B. (2008). Trypanosoma cruzi Infection of cultured adipocytes results in an inflammatory phenotype. Obesity, 16(9), 1992-1997. DOI:10.1038/oby.2008.331
    . Publication link: dbef5f82-f988-4a27-a52c-3464cfc6a5fc | PubMed:19186325
  • Okamoto, T., Okamoto, L., Lisanti, M. P., & Akishita, M. (2008). Switch to oral hypoglycemic agent therapy from insulin injection in patients with type 2 diabetes. Geriatrics and Gerontology International, 8(4), 218-226. DOI:10.1111/j.1447-0594.2008.00477.x
    . Publication link: d6897e2e-6c4d-49c5-8714-a6132edf5c03 | PubMed:19149832
  • Rao, M., Casimiro, M. C., Lisanti, M. P., D'Amico, M., Wang, C., Shirley, L. A., ... Pestell, R. G. (2008). Inhibition of cyclin D1 gene transcription by Brg-1. Cell Cycle, 7(5), 647-655.
    . Publication link: de43a53f-ea46-447b-93bd-e9bdfc8a783c | PubMed:18239461
  • Tamgüney, G., Giles, K., Glidden, D. V., Lessard, P., Wille, H., Tremblay, P., ... Prusiner, S. B. (2008). Genes contributing to prion pathogenesis. Journal of General Virology, 89(7), 1777-1778. DOI:10.1099/vir.0.2008/001255-0
    . Publication link: 3b622127-3e50-4763-8a42-bc0c70f29902 | PubMed:18559949
  • Traverso, M., Gazzerro, E., Assereto, S., Sotgia, F., Biancheri, R., Stringara, S., ... Minetti, C. (2008). Caveolin-3 T78M and T78K missense mutations lead to different phenotypes in vivo and in vitro. Laboratory Investigation, 88(3), 275-283. DOI:10.1038/labinvest.3700713
    . Publication link: 9303eb7b-05f6-4fb4-9ec3-f3d62201f33d | PubMed:18253147
  • Witkiewicz, A. K., Nguyen, K. H., Dasgupta, A., Kennedy, E. P., Yeo, C. J., Lisanti, M. P., & Brody, J. R. (2008). Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: Implications for tumor progression and clinical outcome. Cell Cycle, 7(19), 3021-3025.
    . Publication link: e9fb1dc4-33b6-4ff6-82b5-baed3c0e7715 | PubMed:18802406
  • Wu, K., Katiyar, S., Li, A., Liu, M., Ju, X., Popov, V. M., ... Pestell, R. G. (2008). Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8. Proceedings of the National Academy of Sciences of the United States of America, 105(19), 6924-6929. DOI:10.1073/pnas.0802085105
    . Publication link: dd70192a-ff74-43cd-b80f-b2e4ad3b4840 | PubMed:18467491

2007

  • Hulit, J., Suyama, K., Chung, S., Keren, R., Agiostratidou, G., Shan, W., ... Hazan, R. B. (2007). N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation. Cancer Research, 67(7), 3106-3116. DOI:10.1158/0008-5472.CAN-06-3401
    . Publication link: 8b13ca8f-d083-4ae1-bb66-fa03e5ae7190

2003

  • Sotgia, F., Bonuccelli, G., Bedford, M., Brancaccio, A., Mayer, U., Wilson, M. T., ... Lisanti, M. P. (2003). Localization of phospho-β-dystroglycan (pY892) to an intracellular vesicular compartment in cultured cells and skeletal muscle fibers in vivo. Biochemistry, 42(23), 7110-7123. DOI:10.1021/bi0271289
    . Publication link: 15fe65b1-141c-4a89-98c0-066db4851553 | PubMed:12795607

2002

  • Park, D. S., Lee, H., Frank, P. G., Razani, B., Nguyen, A. V., Parlow, A. F., ... Lisanti, M. P. (2002). Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade. Molecular Biology of the Cell, 13(10), 3416-3430. DOI:10.1091/mbc.02-05-0071
    . Publication link: fc87955a-1eb0-4228-99ba-498cc72fe408

2001

  • Park, D. S., Lee, H., Riedel, C., Hulit, J., Scherer, P. E., Pestell, R. G., & Lisanti, M. P. (2001). Prolactin Negatively Regulates Caveolin-1 Gene Expression in the Mammary Gland during Lactation, via a Ras-dependent Mechanism. Journal of Biological Chemistry, 276(51), 48389-48397.
    . Publication link: 6f9bbe0e-c35f-4796-a626-ee42385fef7c

2000

  • Hulit, J., Bash, T., Fu, M., Galbiati, F., Albanese, C., Sage, D. R., ... Pestell, R. G. (2000). The cyclin D1 gene is transcriptionally repressed by caveolin-1. Journal of Biological Chemistry, 275(28), 21203-21209. DOI:10.1074/jbc.M000321200
    . Publication link: 232d73fb-16b4-49d5-a1f4-55fdbb20e456
  • Zafonte, B. T., Hulit, J., Amanatullah, D. F., Albanese, C., Wang, C., Rosen, E., ... Pestell, R. G. (2000). Cell-cycle dysregulation in breast cancer: breast cancer therapies targeting the cell cycle.Front Biosci, 5, D938-961.
    . Publication link: 76eeac70-30ba-4202-b441-bbd37cd0bd4f